Use of Conditional and Marginal Odds-Ratios for Analysing Familial Aggregation of Binary Data

P.E.B. Fitzgerald, Matthew Knuiman

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We propose a method for measuring familial aggregation of binary outcomes that incorporates unconditional, i.e., marginal, odds-ratios, for measuring association between outcomes within generations while using conditional odds-ratios to measure association between generations. This method may be used together with marginal odds-ratio models to explore the strength of association between individuals within a generation while accounting for the outcomes of predecessors. Interpretation of resulting odds-ratios is straightforward and a number of features of the method are discussed. An example, using smoking status data from Busselton Health Study families, is used to illustrate our approach. (C) 2000 Wiley-Liss, Inc.
Original languageEnglish
Pages (from-to)193-202
JournalGenetic Epidemiology
Volume18
Issue number3
DOIs
Publication statusPublished - 2000

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