Abstract
Introduction
Assessing the cost-effectiveness of therapeutic interventions is increasingly crucial for health decision-making. Spontaneous bacterial peritonitis (SBP) is one of the major complications of liver cirrhosis. The use of albumin in conjunction with antibiotics has been shown to be effective through clinical trials [1].
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Methods
A decision tree (TreeAge®) (Figure (Figure1)1) was populated from published sources for clinical, cost and epidemiologic variables. The perspective taken was that of the US payer. The robustness of the model was checked using one-way and probabilistic sensitivity analyses. The clinical course was followed for 3 months or until death. Total medical costs and quality-adjusted life years (QALYs) [2] were calculated.
Results
Total costs were decreased when using albumin, and the improved survival resulted in an additional QALY for patients on albumin, decreasing the cost per QALY.
Conclusion
The use of albumin in the treatment of SPB is cost-effective.
References
Poca M, Clin Gastroenterol Hepatol. 2012. pp. 309–15. [PubMed] [Cross Ref]
Wells CD, Dig Dis Sci. 2004. pp. 453–8. [PubMed]
Assessing the cost-effectiveness of therapeutic interventions is increasingly crucial for health decision-making. Spontaneous bacterial peritonitis (SBP) is one of the major complications of liver cirrhosis. The use of albumin in conjunction with antibiotics has been shown to be effective through clinical trials [1].
Go to:
Methods
A decision tree (TreeAge®) (Figure (Figure1)1) was populated from published sources for clinical, cost and epidemiologic variables. The perspective taken was that of the US payer. The robustness of the model was checked using one-way and probabilistic sensitivity analyses. The clinical course was followed for 3 months or until death. Total medical costs and quality-adjusted life years (QALYs) [2] were calculated.
Results
Total costs were decreased when using albumin, and the improved survival resulted in an additional QALY for patients on albumin, decreasing the cost per QALY.
Conclusion
The use of albumin in the treatment of SPB is cost-effective.
References
Poca M, Clin Gastroenterol Hepatol. 2012. pp. 309–15. [PubMed] [Cross Ref]
Wells CD, Dig Dis Sci. 2004. pp. 453–8. [PubMed]
| Original language | English |
|---|---|
| Journal | Critical Care |
| Volume | 19(Suppl 1) |
| DOIs | |
| Publication status | Published - 2015 |