Use of a type 1 genetic risk score for classification of diabetes type in young Australian adults: the Fremantle Diabetes Study Phase II

Timothy M.E. Davis; Kirsten E. Peters; Wendy Davis

doi:10.1111/imj.16328

Use of a type 1 genetic risk score for classification of diabetes type in young Australian adults: the Fremantle Diabetes Study Phase II

Timothy M.E. Davis
, Kirsten E. Peters
, Wendy Davis

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The applicability of a UK-validated genetic risk score (GRS) was assessed in 158 participants in the Fremantle Diabetes Study Phase II diagnosed between 20 and <40 years of age with type 1 or type 2 diabetes or latent autoimmune diabetes of adults (LADA). For type 1 versus type 2/LADA, the area under the receiver operating characteristic curve (AUC) was highest for serum C-peptide (0.93) and lowest for the GRS (0.66). Adding age at diagnosis and body mass index to C-peptide increased the AUC minimally (0.96). The GRS appears of modest diabetes diagnostic value in young Australians.

Original language	English
Pages (from-to)	494-498
Number of pages	5
Journal	Internal Medicine Journal
Volume	54
Issue number	3
Early online date	15 Jan 2024
DOIs	https://doi.org/10.1111/imj.16328
Publication status	Published - Mar 2024

Funding

Funders	Funder number
NHMRC National Health and Medical Research Council	1042231, 513781, 1126886, 1154192

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1111/imj.16328Licence: CC BY

Cite this

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title = "Use of a type 1 genetic risk score for classification of diabetes type in young Australian adults: the Fremantle Diabetes Study Phase II",

abstract = "The applicability of a UK-validated genetic risk score (GRS) was assessed in 158 participants in the Fremantle Diabetes Study Phase II diagnosed between 20 and <40 years of age with type 1 or type 2 diabetes or latent autoimmune diabetes of adults (LADA). For type 1 versus type 2/LADA, the area under the receiver operating characteristic curve (AUC) was highest for serum C-peptide (0.93) and lowest for the GRS (0.66). Adding age at diagnosis and body mass index to C-peptide increased the AUC minimally (0.96). The GRS appears of modest diabetes diagnostic value in young Australians.",

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AU - Peters, Kirsten E.

AU - Davis, Wendy

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Use of a type 1 genetic risk score for classification of diabetes type in young Australian adults: the Fremantle Diabetes Study Phase II

Abstract

Funding

UN SDGs

Access to Document

Other files and links

Fingerprint

MRFF - Community-based studies of diabetes and infectious diseases

Development of a multi-faceted diagnostic and predictive tool to characterise type of diabetes, therapeutic progression and outcome

The Fremantle Diabetes Study Phase II - A Community Based Study of Diabetes Care Control Complications & Cost

Cite this

Use of a type 1 genetic risk score for classification of diabetes type in young Australian adults: the Fremantle Diabetes Study Phase II

Abstract

Funding

UN SDGs

Access to Document

Other files and links

Fingerprint

Projects

MRFF - Community-based studies of diabetes and infectious diseases

Development of a multi-faceted diagnostic and predictive tool to characterise type of diabetes, therapeutic progression and outcome

The Fremantle Diabetes Study Phase II - A Community Based Study of Diabetes Care Control Complications & Cost

Cite this