Use of a type 1 genetic risk score for classification of diabetes type in young Australian adults: the Fremantle Diabetes Study Phase II

Timothy M.E. Davis; Kirsten E. Peters; Wendy Davis

doi:10.1111/imj.16328

Use of a type 1 genetic risk score for classification of diabetes type in young Australian adults: the Fremantle Diabetes Study Phase II

Timothy M.E. Davis, Kirsten E. Peters, Wendy Davis

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Abstract

The applicability of a UK-validated genetic risk score (GRS) was assessed in 158 participants in the Fremantle Diabetes Study Phase II diagnosed between 20 and <40 years of age with type 1 or type 2 diabetes or latent autoimmune diabetes of adults (LADA). For type 1 versus type 2/LADA, the area under the receiver operating characteristic curve (AUC) was highest for serum C-peptide (0.93) and lowest for the GRS (0.66). Adding age at diagnosis and body mass index to C-peptide increased the AUC minimally (0.96). The GRS appears of modest diabetes diagnostic value in young Australians.

Original language	English
Pages (from-to)	494-498
Number of pages	5
Journal	Internal Medicine Journal
Volume	54
Issue number	3
Early online date	15 Jan 2024
DOIs	https://doi.org/10.1111/imj.16328
Publication status	Published - Mar 2024

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10.1111/imj.16328Licence: CC BY

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abstract = "The applicability of a UK-validated genetic risk score (GRS) was assessed in 158 participants in the Fremantle Diabetes Study Phase II diagnosed between 20 and <40 years of age with type 1 or type 2 diabetes or latent autoimmune diabetes of adults (LADA). For type 1 versus type 2/LADA, the area under the receiver operating characteristic curve (AUC) was highest for serum C-peptide (0.93) and lowest for the GRS (0.66). Adding age at diagnosis and body mass index to C-peptide increased the AUC minimally (0.96). The GRS appears of modest diabetes diagnostic value in young Australians.",

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Use of a type 1 genetic risk score for classification of diabetes type in young Australian adults: the Fremantle Diabetes Study Phase II

Abstract

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MRFF - Community-based studies of diabetes and infectious diseases

Development of a multi-faceted diagnostic and predictive tool to characterise type of diabetes, therapeutic progression and outcome

The Fremantle Diabetes Study Phase II - A Community Based Study of Diabetes Care Control Complications & Cost

Cite this

Use of a type 1 genetic risk score for classification of diabetes type in young Australian adults: the Fremantle Diabetes Study Phase II

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Projects

MRFF - Community-based studies of diabetes and infectious diseases

Development of a multi-faceted diagnostic and predictive tool to characterise type of diabetes, therapeutic progression and outcome

The Fremantle Diabetes Study Phase II - A Community Based Study of Diabetes Care Control Complications & Cost

Cite this