Use of a type 1 genetic risk score for classification of diabetes type in young Australian adults: the Fremantle Diabetes Study Phase II

Timothy M.E. Davis, Kirsten E. Peters, Wendy Davis

Research output: Contribution to journalArticlepeer-review

Abstract

The applicability of a UK-validated genetic risk score (GRS) was assessed in 158 participants in the Fremantle Diabetes Study Phase II diagnosed between 20 and <40 years of age with type 1 or type 2 diabetes or latent autoimmune diabetes of adults (LADA). For type 1 versus type 2/LADA, the area under the receiver operating characteristic curve (AUC) was highest for serum C-peptide (0.93) and lowest for the GRS (0.66). Adding age at diagnosis and body mass index to C-peptide increased the AUC minimally (0.96). The GRS appears of modest diabetes diagnostic value in young Australians.

Original languageEnglish
Pages (from-to)494-498
Number of pages5
JournalInternal Medicine Journal
Volume54
Issue number3
Early online date15 Jan 2024
DOIs
Publication statusPublished - Mar 2024

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