Use of a handheld terahertz pulsed imaging device to differentiate benign and malignant breast tissue

Maarten R. Grootendorst, Anthony J. Fitzgerald, Susan G.Brouwer De Koning, Aida Santaolalla, Alessia Portieri, Mieke Van Hemelrijck, Matthew R. Young, Julie Owen, Massi Cariati, Michael Pepper, Vincent P. Wallace, Sarah E. Pinder, Arnie Purushotham

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Abstract

    Since nearly 20% of breast-conserving surgeries (BCS) require re-operation, there is a clear need for developing new techniques to more accurately assess tumor resection margins intraoperatively. This study evaluates the diagnostic accuracy of a handheld terahertz pulsed imaging (TPI) system to discriminate benign from malignant breast tissue ex vivo. Forty six freshly excised breast cancer samples were scanned with a TPI handheld probe system, and histology was obtained for comparison. The image pixels on TPI were classified using (1) parameters in combination with support vector machine (SVM) and (2) Gaussian wavelet deconvolution in combination with Bayesian classification. The results were an accuracy, sensitivity, specificity of 75%, 86%, 66% for method 1, and 69%, 87%, 54% for method 2 respectively. This demonstrates the probe can discriminate invasive breast cancer from benign breast tissue with an encouraging degree of accuracy, warranting further study.

    Original languageEnglish
    Article number286058
    JournalBiomedical Optics Express
    Volume8
    Issue number6
    DOIs
    Publication statusPublished - 1 Jun 2017

    Fingerprint

    Terahertz Imaging
    breast
    Breast
    Breast Neoplasms
    Equipment and Supplies
    Segmental Mastectomy
    cancer
    Histology
    histology
    probes
    Sensitivity and Specificity
    surgery
    margins
    tumors
    pixels
    Neoplasms
    sensitivity

    Cite this

    Grootendorst, M. R., Fitzgerald, A. J., De Koning, S. G. B., Santaolalla, A., Portieri, A., Van Hemelrijck, M., ... Purushotham, A. (2017). Use of a handheld terahertz pulsed imaging device to differentiate benign and malignant breast tissue. Biomedical Optics Express, 8(6), [286058]. https://doi.org/10.1364/BOE.8.002932
    Grootendorst, Maarten R. ; Fitzgerald, Anthony J. ; De Koning, Susan G.Brouwer ; Santaolalla, Aida ; Portieri, Alessia ; Van Hemelrijck, Mieke ; Young, Matthew R. ; Owen, Julie ; Cariati, Massi ; Pepper, Michael ; Wallace, Vincent P. ; Pinder, Sarah E. ; Purushotham, Arnie. / Use of a handheld terahertz pulsed imaging device to differentiate benign and malignant breast tissue. In: Biomedical Optics Express. 2017 ; Vol. 8, No. 6.
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    abstract = "Since nearly 20{\%} of breast-conserving surgeries (BCS) require re-operation, there is a clear need for developing new techniques to more accurately assess tumor resection margins intraoperatively. This study evaluates the diagnostic accuracy of a handheld terahertz pulsed imaging (TPI) system to discriminate benign from malignant breast tissue ex vivo. Forty six freshly excised breast cancer samples were scanned with a TPI handheld probe system, and histology was obtained for comparison. The image pixels on TPI were classified using (1) parameters in combination with support vector machine (SVM) and (2) Gaussian wavelet deconvolution in combination with Bayesian classification. The results were an accuracy, sensitivity, specificity of 75{\%}, 86{\%}, 66{\%} for method 1, and 69{\%}, 87{\%}, 54{\%} for method 2 respectively. This demonstrates the probe can discriminate invasive breast cancer from benign breast tissue with an encouraging degree of accuracy, warranting further study.",
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    Grootendorst, MR, Fitzgerald, AJ, De Koning, SGB, Santaolalla, A, Portieri, A, Van Hemelrijck, M, Young, MR, Owen, J, Cariati, M, Pepper, M, Wallace, VP, Pinder, SE & Purushotham, A 2017, 'Use of a handheld terahertz pulsed imaging device to differentiate benign and malignant breast tissue' Biomedical Optics Express, vol. 8, no. 6, 286058. https://doi.org/10.1364/BOE.8.002932

    Use of a handheld terahertz pulsed imaging device to differentiate benign and malignant breast tissue. / Grootendorst, Maarten R.; Fitzgerald, Anthony J.; De Koning, Susan G.Brouwer; Santaolalla, Aida; Portieri, Alessia; Van Hemelrijck, Mieke; Young, Matthew R.; Owen, Julie; Cariati, Massi; Pepper, Michael; Wallace, Vincent P.; Pinder, Sarah E.; Purushotham, Arnie.

    In: Biomedical Optics Express, Vol. 8, No. 6, 286058, 01.06.2017.

    Research output: Contribution to journalArticle

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    AU - Fitzgerald, Anthony J.

    AU - De Koning, Susan G.Brouwer

    AU - Santaolalla, Aida

    AU - Portieri, Alessia

    AU - Van Hemelrijck, Mieke

    AU - Young, Matthew R.

    AU - Owen, Julie

    AU - Cariati, Massi

    AU - Pepper, Michael

    AU - Wallace, Vincent P.

    AU - Pinder, Sarah E.

    AU - Purushotham, Arnie

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    AB - Since nearly 20% of breast-conserving surgeries (BCS) require re-operation, there is a clear need for developing new techniques to more accurately assess tumor resection margins intraoperatively. This study evaluates the diagnostic accuracy of a handheld terahertz pulsed imaging (TPI) system to discriminate benign from malignant breast tissue ex vivo. Forty six freshly excised breast cancer samples were scanned with a TPI handheld probe system, and histology was obtained for comparison. The image pixels on TPI were classified using (1) parameters in combination with support vector machine (SVM) and (2) Gaussian wavelet deconvolution in combination with Bayesian classification. The results were an accuracy, sensitivity, specificity of 75%, 86%, 66% for method 1, and 69%, 87%, 54% for method 2 respectively. This demonstrates the probe can discriminate invasive breast cancer from benign breast tissue with an encouraging degree of accuracy, warranting further study.

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