Urinary Leukotriene E4 and 9α, 11β-prostaglandin F2 concentrations in mild, moderate and severe asthma, and in healthy subjects

Neil Misso, S. Aggarwal, S. Phelps, R. Beard, Philip Thompson

    Research output: Contribution to journalArticle

    20 Citations (Scopus)

    Abstract

    Background Airway inflammation in asthma is associated with cysteinyl leukotriene and prostaglandin D2 production. Measurement of urinary metabolites of these eicosanoids may be useful for monitoring asthma patients. However, the influence of asthma phenotype and severity on basal urinary excretion of these metabolites is unknown.Objective To compare urinary leukotriene (LT)E4 and 9α, 11β-prostaglandin (PG)F2 concentrations in large groups of mild, moderate and severe asthmatic patients and healthy control subjects.Methods Asthma severity, treatment and aspirin sensitivity were assessed by questionnaire in 168 asthmatic patients. Basal LTE4 and 9α, 11β-PGF2 concentrations were measured in urine samples from these patients and from 175 control subjects using enzyme immunoassays.Results Urinary LTE4 was correlated with 9α, 11β-PGF2 in both control subjects and asthmatic patients (P
    Original languageEnglish
    Pages (from-to)624-631
    JournalClinical and Experimental Allergy
    Volume34
    Issue number4
    DOIs
    Publication statusPublished - 2004

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