Urinary bladder auto augmentation using INTEGRA® and SURGISIS® : an experimental model

P.K. Gera, Andrew Paul Barker, S. Ahmen, G. Jevon, Jillian Orford

    Research output: Contribution to journalArticlepeer-review


    ObjectiveWe present our experience with an experimental urinary bladder auto augmentation model using SURGISIS® and INTEGRA® (collagen layer) in comparison with seromuscular enterocystoplasty. The aim of the study was to evaluate the change in compliance and elasticity of the urinary bladder.Materials and methodsEighteen lambs were divided into three different groups. Auto augmentation was performed using the seromuscular layer of small bowel, SURGISIS® or the collagen layer of INTEGRA®. After 3 months of the initial procedure, the lambs were re-operated, the bladder compliance was measured and the urinary bladder was submitted for histological examination and assessment of elasticity. The lambs were euthanized.ResultsThe postoperative period was uneventful in 17 lambs except for intestinal obstruction in one lamb from the seromuscular enterocystoplasty group. A statistically significant difference in compliance was observed with SURGISIS® and the INTEGRA®. Histologically, there was neovascularization in all the specimens from the SURGISIS® and INTEGRA® groups with the presence of fibrosis in the SURGISIS® group. The INTEGRA® group showed better elastic properties than the SURGISIS®.ConclusionsUrinary bladder auto augmentation using the collagen layer of INTEGRA® showed better functional and histological results when compared with SURGISIS® and demucosalized enterocystoplasty in the present model.
    Original languageEnglish
    Pages (from-to)N/A
    JournalPediatric Surgery International
    Issue number3
    Publication statusPublished - 2009


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