Urea : diverse functions of a 'waste' product

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    Abstract

    1. The urea cycle is essentially the simultaneous operation of two linear pathways, both primitive and widespread among animals; one is for arginine synthesis and the other is for arginine degradation to ornithine and urea.2. All animals may have the genetic capacity to express a urea cycle and many diverse groups of animals, from flatworms to mammals, have a functional urea cycle.3. Evolutionary changes in vertebrates of carbamylphosphate synthetase (CPS) are directed from glutamine-dependent (CPSIII) towards NH3-dependent (CPSI) ureagenesis. Invertebrates, cartilagenous fish and the coelacanth have CPSIII (i,e, glutamine-dependent), whereas lungfish, amphibians and amniote vertebrates have CPSI; the teleost Heteropneustes has CPSI-like activity. That the coelacanth has CPSIII and Heteropneustes has 'CPSI' suggests that the form of CPS may by physiologically related (CPSIII in a balancing solute role and CPSI in a terrestrial, air-breathing excretion role) rather than being phylogenetically constrained. it,4. Urea is a major balancing osmolyte in marine cartilagenous fish, the coelacanth and a few amphibians and some aestivating terrestrial amphibians. It is a storage osmolyte in cocoon-forming aestivating lungfish and amphibians.5, Urea contributes towards positive buoyancy in marine cartilagenous fish.6, Urea functions for non-toxic N transport in ruminant and pseudoruminant mammals7, Urea is a major solute in the mammalian (but not avian) kidney, contributing to a renal medullary osmotic gradient; it is substantially reabsorbed by mammalian nephrons,8, Urea is used as a preferred nitrogenous waste compared with ammonia at high ambient pNH(3) or pH, with water restriction, or air breathing.9, Urea synthesis maintains acid-base balance by the 1:1 stoichiometry of removal of HCO3- and NH4+.
    Original languageEnglish
    Pages (from-to)722-727
    JournalClinical and Experimental Pharmacology and Physiology
    Volume25
    DOIs
    Publication statusPublished - 1998

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