Upregulation of Endogenous Intrahepatic Interferon Stimulated Genes During Chronic Hepatitis C Virus Infection

Gerry Macquillan; C. Mamotte; William Reed; Gary Jeffrey; Jane Allan

doi:10.1002/jmv.10381

Upregulation of Endogenous Intrahepatic Interferon Stimulated Genes During Chronic Hepatitis C Virus Infection

Gerry Macquillan, C. Mamotte, William Reed, Gary Jeffrey, Jane Allan

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Abstract

The success of interferon-α and ribavirin combination therapy for the treatment of chronic hepatitis C viral infection differs between patients. In an attempt to identify predictors of host response to therapy, the levels of mRNA for interferon (IFN) stimulated genes: MxA, PKR, 2′5′ OAS, ISG15, and interleukin 8 (IL-8), were examined in liver by real-time RT-PCR prior to commencement of therapy. The levels of intrahepatic classical IFN stimulated genes, but not IL-8, in chronic HCV disease (n = 44) were found to be significantly upregulated (P

Original language	English
Pages (from-to)	219-227
Journal	Journal of Medical Virology
Volume	70
Issue number	2
DOIs	https://doi.org/10.1002/jmv.10381
Publication status	Published - 2003

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Macquillan, G., Mamotte, C., Reed, W., Jeffrey, G., & Allan, J. (2003). Upregulation of Endogenous Intrahepatic Interferon Stimulated Genes During Chronic Hepatitis C Virus Infection. Journal of Medical Virology, 70(2), 219-227. https://doi.org/10.1002/jmv.10381

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10.1002/jmv.10381