Upregulation of Endogenous Intrahepatic Interferon Stimulated Genes During Chronic Hepatitis C Virus Infection

Research output: Contribution to journalArticle

57 Citations (Scopus)


The success of interferon-α and ribavirin combination therapy for the treatment of chronic hepatitis C viral infection differs between patients. In an attempt to identify predictors of host response to therapy, the levels of mRNA for interferon (IFN) stimulated genes: MxA, PKR, 2′5′ OAS, ISG15, and interleukin 8 (IL-8), were examined in liver by real-time RT-PCR prior to commencement of therapy. The levels of intrahepatic classical IFN stimulated genes, but not IL-8, in chronic HCV disease (n = 44) were found to be significantly upregulated (P 
Original languageEnglish
Pages (from-to)219-227
JournalJournal of Medical Virology
Issue number2
Publication statusPublished - 2003


Cite this