Upregulation of Endogenous Intrahepatic Interferon Stimulated Genes During Chronic Hepatitis C Virus Infection

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Abstract

The success of interferon-α and ribavirin combination therapy for the treatment of chronic hepatitis C viral infection differs between patients. In an attempt to identify predictors of host response to therapy, the levels of mRNA for interferon (IFN) stimulated genes: MxA, PKR, 2′5′ OAS, ISG15, and interleukin 8 (IL-8), were examined in liver by real-time RT-PCR prior to commencement of therapy. The levels of intrahepatic classical IFN stimulated genes, but not IL-8, in chronic HCV disease (n = 44) were found to be significantly upregulated (P 
Original languageEnglish
Pages (from-to)219-227
JournalJournal of Medical Virology
Volume70
Issue number2
DOIs
Publication statusPublished - 2003

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