Update on genomic and molecular landscapes of well-differentiated liposarcoma and dedifferentiated liposarcoma

Jun Lu, David Wood, Evan Ingley, Sulev Koks, Daniel Wong

Research output: Contribution to journalReview article

Abstract

Well-differentiated liposarcoma (WDLPS) is the most frequent subtype of liposarcoma and may transform into dedifferentiated liposarcoma (DDLPS) which is a more aggressive subtype. Retroperitoneal lesions of WDLPS/DDLPS tend to recur repeatedly due to incomplete resections, and adjuvant chemotherapy and radiotherapy have little effect on patient survival. Consequently, identifying therapeutic targets and developing targeted drugs is critical for improving the outcome of WDLPS/DDLPS patients. In this review, we summarised the mutational landscape of WDLPS/DDLPS from recent studies focusing on potential oncogenic drivers and the development of molecular targeted drugs for DDLPS. Due to the limited number of studies on the molecular networks driving WDLPS to DDLPS development, we looked at other dedifferentiation-related tumours to identify potential parallel mechanisms that could be involved in the dedifferentiation process generating DDLPS.

Original languageEnglish
JournalMolecular Biology Reports
DOIs
Publication statusE-pub ahead of print - 24 Apr 2021

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