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Abstract
Hypothesis: The forces that govern lipid self-assembly ionic liquids are similar to water, but their different balance can result in unexpected behaviour. Experiments: The self-assembly behaviour and phase equilibria of two phospholipids, 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), in the most common protic ionic liquid, ethylammonium nitrate (EAN) have been investigated as function of composition and temperature by small- and wide-angle X-ray scattering (SAXS/WAXS) and small-angle neutron scattering (SANS). Findings: Both lipids form unusual self-assembly structures and show complex and unexpected phase behaviour unlike that seen in water; DSPC undergoes a gel Lβ to crystalline Lc phase transition on warming, while POPC forms worm-like micelles L1 upon dilution. This surprising phase behaviour is attributed to the large size of the EAN ions that solvate the lipid headgroup compared to water changing amphiphile packing. Weaker H-bonding between EAN and lipid headgroups also contributes. These results provide new insight for the design of lipid based nanostructured materials in ionic liquids with atypical properties.
Original language | English |
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Pages (from-to) | 276-281 |
Number of pages | 6 |
Journal | Journal of Colloid and Interface Science |
Volume | 643 |
DOIs | |
Publication status | Published - Aug 2023 |
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Dive into the research topics of 'Unusual phosphatidylcholine lipid phase behavior in the ionic liquid ethylammonium nitrate'. Together they form a unique fingerprint.Projects
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Nanostructured Ionic-Molecular Hybrid Liquids
Warr, G., Atkin, R., Perkin, S. & Edlar, K.
1/01/20 → 31/12/23
Project: Research