Unusual paediatric spinal myxopapillary ependymomas: Unique molecular entities or pathological variations on a theme?

Sasha Rogers, David T.W. Jones, Amanda Ireland, Nick G. Gottardo, Raelene Endersby

Research output: Contribution to journalArticle

Abstract

Ependymomas are the commonest type of spinal glioma which represent a group of relatively benign tumours. Myxopapillary ependymoma (MPE) is a common variant found within the distal spinal cord around the conus. These two entities are clearly differentiated on the basis of their characteristic histological and molecular features. Rare variants of MPE's are described in the literature to have the propensity to metastasise and grow in extraspinal locations despite appearing histologically identical to their more benign relatives. Here, we describe two unusual cases of MPE and utilise DNA methylation analyses to compare their molecular signatures with known molecular subtypes of ependymoma in an attempt to distinguish whether these tumours represent a unique subset of disease.

Original languageEnglish
Pages (from-to)144-148
JournalJournal of Clinical Neuroscience
Volume50
DOIs
Publication statusPublished - Apr 2018

Fingerprint

Ependymoma
Pediatrics
DNA Methylation
Glioma
Neoplasms
Spinal Cord

Cite this

@article{432b7fc4d597446986f9444ac9f2de85,
title = "Unusual paediatric spinal myxopapillary ependymomas: Unique molecular entities or pathological variations on a theme?",
abstract = "Ependymomas are the commonest type of spinal glioma which represent a group of relatively benign tumours. Myxopapillary ependymoma (MPE) is a common variant found within the distal spinal cord around the conus. These two entities are clearly differentiated on the basis of their characteristic histological and molecular features. Rare variants of MPE's are described in the literature to have the propensity to metastasise and grow in extraspinal locations despite appearing histologically identical to their more benign relatives. Here, we describe two unusual cases of MPE and utilise DNA methylation analyses to compare their molecular signatures with known molecular subtypes of ependymoma in an attempt to distinguish whether these tumours represent a unique subset of disease.",
keywords = "Myxopapillary ependymoma, Paediatric, Spine",
author = "Sasha Rogers and Jones, {David T.W.} and Amanda Ireland and Gottardo, {Nick G.} and Raelene Endersby",
year = "2018",
month = "4",
doi = "10.1016/j.jocn.2018.01.048",
language = "English",
volume = "50",
pages = "144--148",
journal = "Journal of Clinical Neuroscience",
issn = "0967-5868",
publisher = "Churchill Livingstone",

}

Unusual paediatric spinal myxopapillary ependymomas : Unique molecular entities or pathological variations on a theme? / Rogers, Sasha; Jones, David T.W.; Ireland, Amanda; Gottardo, Nick G.; Endersby, Raelene.

In: Journal of Clinical Neuroscience, Vol. 50, 04.2018, p. 144-148.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Unusual paediatric spinal myxopapillary ependymomas

T2 - Unique molecular entities or pathological variations on a theme?

AU - Rogers, Sasha

AU - Jones, David T.W.

AU - Ireland, Amanda

AU - Gottardo, Nick G.

AU - Endersby, Raelene

PY - 2018/4

Y1 - 2018/4

N2 - Ependymomas are the commonest type of spinal glioma which represent a group of relatively benign tumours. Myxopapillary ependymoma (MPE) is a common variant found within the distal spinal cord around the conus. These two entities are clearly differentiated on the basis of their characteristic histological and molecular features. Rare variants of MPE's are described in the literature to have the propensity to metastasise and grow in extraspinal locations despite appearing histologically identical to their more benign relatives. Here, we describe two unusual cases of MPE and utilise DNA methylation analyses to compare their molecular signatures with known molecular subtypes of ependymoma in an attempt to distinguish whether these tumours represent a unique subset of disease.

AB - Ependymomas are the commonest type of spinal glioma which represent a group of relatively benign tumours. Myxopapillary ependymoma (MPE) is a common variant found within the distal spinal cord around the conus. These two entities are clearly differentiated on the basis of their characteristic histological and molecular features. Rare variants of MPE's are described in the literature to have the propensity to metastasise and grow in extraspinal locations despite appearing histologically identical to their more benign relatives. Here, we describe two unusual cases of MPE and utilise DNA methylation analyses to compare their molecular signatures with known molecular subtypes of ependymoma in an attempt to distinguish whether these tumours represent a unique subset of disease.

KW - Myxopapillary ependymoma

KW - Paediatric

KW - Spine

UR - http://www.scopus.com/inward/record.url?scp=85041347714&partnerID=8YFLogxK

U2 - 10.1016/j.jocn.2018.01.048

DO - 10.1016/j.jocn.2018.01.048

M3 - Article

VL - 50

SP - 144

EP - 148

JO - Journal of Clinical Neuroscience

JF - Journal of Clinical Neuroscience

SN - 0967-5868

ER -