Unusual Case of Combined Gliomeningeal Heterotopia on the Nose of an Infant

Anna Schauer, Nathan T. Harvey, Shyan Vijayasekaran, Benjamin A. Wood

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Nasal glial heterotopia ("nasal glioma") and cutaneous heterotopic meningeal nodules ("primary cutaneous meningioma") are rare congenital lesions characterized by the presence of heterotopic mature cerebral tissues. Nasal glial heterotopia occurs predominantly in the nasal area and typically does not contain meningothelial elements, whereas heterotopic meningeal nodules occur predominantly on the scalp and do not contain glial elements. In this article, we report an unusual case of cutaneous heterotopia on the nose of an infant composed of both glial and meningothelial elements. The glial component was characterized by irregular islands of predominantly astrocytic cells, on a fibrillary background. The meningothelial component was characterized by bland ovoid cells with focal intranuclear inclusions forming whorled arrangements, with associated psammomatous calcification. To our knowledge, this is the first time such a lesion has been documented. It has also provided us with an opportunity to review the literature regarding heterotopic deposits of both glial and meningothelial tissues.

Original languageEnglish
Pages (from-to)515-518
Number of pages4
JournalThe American Journal of dermatopathology
Volume40
Issue number7
DOIs
Publication statusPublished - 1 Jul 2018

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Nose
Neuroglia
Skin
Intranuclear Inclusion Bodies
Meningioma
Scalp
Islands
Glioma

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abstract = "Nasal glial heterotopia ({"}nasal glioma{"}) and cutaneous heterotopic meningeal nodules ({"}primary cutaneous meningioma{"}) are rare congenital lesions characterized by the presence of heterotopic mature cerebral tissues. Nasal glial heterotopia occurs predominantly in the nasal area and typically does not contain meningothelial elements, whereas heterotopic meningeal nodules occur predominantly on the scalp and do not contain glial elements. In this article, we report an unusual case of cutaneous heterotopia on the nose of an infant composed of both glial and meningothelial elements. The glial component was characterized by irregular islands of predominantly astrocytic cells, on a fibrillary background. The meningothelial component was characterized by bland ovoid cells with focal intranuclear inclusions forming whorled arrangements, with associated psammomatous calcification. To our knowledge, this is the first time such a lesion has been documented. It has also provided us with an opportunity to review the literature regarding heterotopic deposits of both glial and meningothelial tissues.",
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Unusual Case of Combined Gliomeningeal Heterotopia on the Nose of an Infant. / Schauer, Anna; Harvey, Nathan T.; Vijayasekaran, Shyan; Wood, Benjamin A.

In: The American Journal of dermatopathology, Vol. 40, No. 7, 01.07.2018, p. 515-518.

Research output: Contribution to journalArticle

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