Unravelling the structural function relationship of DNA secondary structures

Arnold Ou

Research output: ThesisDoctoral Thesis

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Abstract

G-quadruplexes or G4s are secondary DNA structures found in the genome. G4s have been implicated in a range of diseases such as cancer. Because of this, G4s are becoming attractive targets for drug therapies, as it has been shown that stabilization of G4s can alter cancer gene expression. In this work, we developed a new family of multicarbazole ligands, which show unprecedented selectivity towards the KRAS G4, a prominent oncogene. Using our obtained crystal structure of the KRAS G4, we performed modeling studies to reveal the unique binding between the KRAS G4 and our ligands.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Thesis sponsors
Award date23 Oct 2019
DOIs
Publication statusUnpublished - 2019

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