Unravelling inversions: Technological advances, challenges, and potential impact on crop breeding

Haifei Hu, Armin Scheben, Jian Wang, Fangping Li, Chengdao Li, David Edwards, Junliang Zhao

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

Inversions, a type of chromosomal structural variation, significantly influence plant adaptation and gene functions by impacting gene expression and recombination rates. However, compared with other structural variations, their roles in functional biology and crop improvement remain largely unexplored. In this review, we highlight technological and methodological advancements that have allowed a comprehensive understanding of inversion variants through the pangenome framework and machine learning algorithms. Genome editing is an efficient method for inducing or reversing inversion mutations in plants, providing an effective mechanism to modify local recombination rates. Given the potential of inversions in crop breeding, we anticipate increasing attention on inversions from the scientific community in future research and breeding applications.

Original languageEnglish
Pages (from-to)544-554
Number of pages11
JournalPlant Biotechnology Journal
Volume22
Issue number3
Early online date14 Nov 2023
DOIs
Publication statusPublished - Mar 2024

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