Unlocking the immunology of pertussis vaccines to guide the development of improved vaccines and schedules in Australia

Sonia McAlister

doi:10.26182/2b6x-6588

Unlocking the immunology of pertussis vaccines to guide the development of improved vaccines and schedules in Australia

Sonia McAlister

UWA Medical School

Research output: Thesis › Doctoral Thesis

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Abstract

Despite high vaccine uptake, pertussis remains poorly controlled in Australia and elsewhere. This has led to frequent changes in national vaccination policy, often without considering local immuno-epidemiological data to guide best practice and support these decisions. This thesis: 1) described the establishment of high-throughput vaccine-serological assays specific to Tetanus, diphtheria and pertussis (Tdap), 23 pneumococcal serotypes, Haemophilus influenzae type B and Hepatitis-BIgG, and 2) assessed immunogenicity and reactogenicity of alternative pertussis vaccination strategies in Australian populations, including neonatal vaccination; optimal infant booster antigen dosage; alternative infant-schedules; required frequency of adult boosters; and impact of repeat maternal Tdap boosting on infant vaccine responses.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Richmond, Peter, Supervisor Van Den Biggelaar, Anita, Supervisor Thornton, Ruth, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	9 Sept 2024
DOIs	https://doi.org/10.26182/2b6x-6588
Publication status	Unpublished - 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.26182/2b6x-6588

THESIS - DOCTOR OF PHILOSOPHY - MCALISTER Sonia May - 2023
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2 Article

An observational study of antibody responses to a primary or subsequent pertussis booster vaccination in Australian healthcare workers
McAlister, S. M., van den Biggelaar, A. H. J., Woodman, T. L., Hutton, H., Thornton, R. B. & Richmond, P. C., 12 Mar 2021, In: Vaccine. 39, 11, p. 1642-1651 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
7 Citations (Scopus)
Optimising a 6-plex tetanus-diphtheria-pertussis fluorescent bead-based immunoassay
McAlister, S. M., van den Biggelaar, A. H. J., Thornton, R. B. & Richmond, P. C., Jan 2021, In: MethodsX. 8, 101360.
Research output: Contribution to journal › Article › peer-review

Open Access
8 Citations (Scopus)

Cite this

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title = "Unlocking the immunology of pertussis vaccines to guide the development of improved vaccines and schedules in Australia",

abstract = "Despite high vaccine uptake, pertussis remains poorly controlled in Australia and elsewhere. This has led to frequent changes in national vaccination policy, often without considering local immuno-epidemiological data to guide best practice and support these decisions. This thesis: 1) described the establishment of high-throughput vaccine-serological assays specific to Tetanus, diphtheria and pertussis (Tdap), 23 pneumococcal serotypes, Haemophilus influenzae type B and Hepatitis-BIgG, and 2) assessed immunogenicity and reactogenicity of alternative pertussis vaccination strategies in Australian populations, including neonatal vaccination; optimal infant booster antigen dosage; alternative infant-schedules; required frequency of adult boosters; and impact of repeat maternal Tdap boosting on infant vaccine responses.",

keywords = "Pertussis, Whooping cough, Antibody, Vaccine, Immunisation schedule, maternal vaccination, immune interference, immune-blunting",

author = "Sonia McAlister",

year = "2023",

doi = "10.26182/2b6x-6588",

language = "English",

school = "The University of Western Australia",

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TY - BOOK

T1 - Unlocking the immunology of pertussis vaccines to guide the development of improved vaccines and schedules in Australia

AU - McAlister, Sonia

PY - 2023

Y1 - 2023

N2 - Despite high vaccine uptake, pertussis remains poorly controlled in Australia and elsewhere. This has led to frequent changes in national vaccination policy, often without considering local immuno-epidemiological data to guide best practice and support these decisions. This thesis: 1) described the establishment of high-throughput vaccine-serological assays specific to Tetanus, diphtheria and pertussis (Tdap), 23 pneumococcal serotypes, Haemophilus influenzae type B and Hepatitis-BIgG, and 2) assessed immunogenicity and reactogenicity of alternative pertussis vaccination strategies in Australian populations, including neonatal vaccination; optimal infant booster antigen dosage; alternative infant-schedules; required frequency of adult boosters; and impact of repeat maternal Tdap boosting on infant vaccine responses.

AB - Despite high vaccine uptake, pertussis remains poorly controlled in Australia and elsewhere. This has led to frequent changes in national vaccination policy, often without considering local immuno-epidemiological data to guide best practice and support these decisions. This thesis: 1) described the establishment of high-throughput vaccine-serological assays specific to Tetanus, diphtheria and pertussis (Tdap), 23 pneumococcal serotypes, Haemophilus influenzae type B and Hepatitis-BIgG, and 2) assessed immunogenicity and reactogenicity of alternative pertussis vaccination strategies in Australian populations, including neonatal vaccination; optimal infant booster antigen dosage; alternative infant-schedules; required frequency of adult boosters; and impact of repeat maternal Tdap boosting on infant vaccine responses.

KW - Pertussis

KW - Whooping cough

KW - Antibody

KW - Vaccine

KW - Immunisation schedule

KW - maternal vaccination

KW - immune interference

KW - immune-blunting

U2 - 10.26182/2b6x-6588

DO - 10.26182/2b6x-6588

M3 - Doctoral Thesis

ER -

Unlocking the immunology of pertussis vaccines to guide the development of improved vaccines and schedules in Australia

Abstract

UN SDGs

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Research output

An observational study of antibody responses to a primary or subsequent pertussis booster vaccination in Australian healthcare workers

Optimising a 6-plex tetanus-diphtheria-pertussis fluorescent bead-based immunoassay

Cite this