Unlocking immune-mediated disease mechanisms with transcriptomics

Research output: Contribution to journalReview article

Abstract

The transcriptome represents the entire set of RNA transcripts expressed in a cell, reflecting both the underlying genetic and epigenetic landscape and environmental influences, providing a comprehensive view of functional cellular states at any given time. Recent technological advances now enable the study of the transcriptome at the resolution of individual cells, providing exciting opportunities to characterise cellular and molecular events that underpin immune-medicated diseases. Here, we draw on recent examples from the literature to highlight the application of advanced bioinformatics tools to extract mechanistic insight and disease biology from bulk and single-cell transcriptomic profiles. Key considerations for the use of available analysis techniques are presented throughout.

Original languageEnglish
Pages (from-to)705-714
Number of pages10
JournalBiochemical Society Transactions
Volume49
Issue number2
DOIs
Publication statusPublished - Apr 2021

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