While well-established as distinct disorders, new evidence linking autism and schizophrenia has emerged. One line of evidence is the strong correlation identified between the social traits assessed by the Autism Spectrum Quotient (AQ:Social) and the negative traits of schizotypy. To further explore this association, the current study examined whether these sets of traits are convergent or divergent in the degree to which they relate to specific aspects of socio-emotional functioning. Regression analyses conducted on self-report data collected from 284 undergraduate students showed that the social items from the AQ uniquely relate to levels of social anxiety and social skills, while negative schizotypy traits uniquely relate to social anhedonia and depression. Additionally, AQ:Social and negative schizotypy traits were found to share a significant proportion of variance, independent of each of the socio-emotional variables examined. The results thus provide further evidence of shared atypical social function linked to both autistic-like traits and negative schizotypy traits, but importantly also highlight clear differences in the specific socio-emotional profiles associated with these sets of traits. © 2013 Elsevier Ltd.