Unique architectural features of mammalian mitochondrial protein synthesis

Oliver Rackham, Martin Saurer, Nenad Ban, Aleksandra Filipovska

Research output: Contribution to journalReview articlepeer-review

Abstract

Mitochondria rely on coordinated expression of their own mitochondrial DNA (mtDNA) with that of the nuclear genome for their biogenesis. The bacterial ancestry of mitochondria has given rise to unique and idiosyncratic features of the mtDNA and its expression machinery that can be specific to different organisms. In animals, the mitochondrial protein synthesis machinery has acquired many new components and mechanisms over evolution. These include several new ribosomal proteins, new stop codons and ways to recognise them, and new mechanisms to deliver nascent proteins into the mitochondrial inner membrane. Here we describe the mitochondrial protein synthesis machinery in mammals and its unique mechanisms of action elucidated to date and highlight the technologies poised to reveal the next generation of discoveries in mitochondrial translation.

Original languageEnglish
Pages (from-to)11-23
Number of pages13
JournalTrends in Cell Biology
Volume35
Issue number1
Early online dateJun 2024
DOIs
Publication statusPublished - Jan 2025

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