Unhealthy Nutrigenomic Diets Accelerate NAFLD and Adiposity in Global Communites

Research output: Contribution to conferenceAbstract

Abstract


The understanding of genetic factors involved in the risk for obesity has identified genes that are closely linked to obesity related diseases. A single gene effect versus multiple genes effect may indicate either the interaction unique to various environments that regulate abnormal molecular or cellular events responsible for obesity/Alzheimer’s disease. Epigenetic modifications in various communities are now closely involved in NAFLD associated with excess transfer of fat to the adipose tissue and the induction of obesity in developed countries. Epigenetic modifications induced by unhealthy diets and the environment effect nuclear/mitochondria interactions and implicate nuclear receptors such as Sirtuin 1 as a single gene effect with interactions with microRNA and transcription factors such as p53 that regulate cellular and immune events with effects on adipose tissue lipid metabolism in obesity and the metabolism of amyloid beta peptide in Alzheimer’s disease (Ref1). Global populations include individuals from various racial groups such as Caucasians, Africans Europeans, Hispanics, Native Americans, Pacific Islanders or Asians. Diets that activate the anti-aging gene Sirt 1 repair chromatin structure and reduce brain bacterial lipopolysaccharide and xenobiotic levels with an improvement in brain circuitry and activation of thinking and intelligence in individuals with NAFLD, obesity and Alzheimer’s disease in global populations
Original languageEnglish
Publication statusPublished - 22 Feb 2017
EventInternational Conference on Genomic Medicine (Gene-Med-2017) - Baltimore , United States
Duration: 22 Feb 201724 Feb 2017

Conference

ConferenceInternational Conference on Genomic Medicine (Gene-Med-2017)
CountryUnited States
CityBaltimore
Period22/02/1724/02/17

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    Martins, I. (2017). Unhealthy Nutrigenomic Diets Accelerate NAFLD and Adiposity in Global Communites. Abstract from International Conference on Genomic Medicine (Gene-Med-2017) , Baltimore , United States.