Understanding the relationship between testosterone and cognition in cognitively healthy older men: An examination of potential mediating and moderating factors

This thesis contributed to the understanding of the relationship between testosterone and cognition in older men. Age-related decrease in testosterone levels is a risk factor for cognitive decline, but research findings have been inconsistent. A meta-analytic review of clinical trials support the potential for testosterone supplementation to prevent cognitive decline. Results from novel experimental studies indicate that this relationship is impacted by genetic variations in the androgen receptor gene and the multiplicative effects of both low and decreasing free testosterone levels. These findings will help inform future clinical trials examining the efficacy of testosterone supplementation in preventing dementia.