Understanding the pathogenesis of obstructive sleep apnoea in children

Tulia Mateus Rugeles

Research output: ThesisDoctoral Thesis

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Abstract

The pathogenesis of obstructive sleep apnoea (OSA) in children remains uncertain. In this cross-sectional study, children with OSA and/or recurrent tonsillitis (RT) had similar prevalence of allergy, inflammation and obesity to healthy controls. Investigation of bacterial density in the nasopharynx, throat, adenoids and tonsils found high densities of non-typeable H. influenzae and S.aureus in tonsillar tissue in both OSA and RT associated with bacterial biofilm and higher densities in throat swabs compared to controls. Pathogen-specific serum and salivary antibodies were generally similar or higher in children with adenotonsillar diseases. Persistent bacterial infection appears important in both paediatric OSA and RT.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Richmond, Peter, Supervisor
  • Thornton, Ruth, Supervisor
  • Kirkham, Lea-Ann, Supervisor
Thesis sponsors
Award date9 Sept 2020
DOIs
Publication statusUnpublished - 2019

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