Understanding the molecular mechanisms through which maternal exposure to Toxoplasma gondii contributes to congenital toxoplasmosis

Wai Fong Genevieve Syn

    Research output: ThesisDoctoral Thesis

    364 Downloads (Pure)

    Abstract

    Toxoplasma gondii is a parasite capable of infecting all warm-blooded animals, including humans. In healthy people, initial infection results in mild symptoms but chronic infection is potentially associated with disorders such as schizophrenia and Parkinson's disease. For a mother infected with Toxoplasma for the first time during pregnancy, her baby may be born with eye and brain diseases. This thesis has identified host processes which are disrupted during Toxoplasma infection including the brain-related dopamine and amyloid pathways and the host mitochondria, which generate energy for the cell. These pathways may serve as new therapeutic targets to treat toxoplasmosis.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Supervisors/Advisors
    • Blackwell, Jenefer, Supervisor
    • Peacock, Christopher, Supervisor
    • Jamieson, Sarra, Supervisor
    Award date7 Jul 2017
    DOIs
    Publication statusUnpublished - 2017

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