Understanding the molecular and physiological consequences of dysregulated mitochondrial gene expression using mouse models of mitochondrial dysfunction

Kara Perks

Research output: ThesisDoctoral Thesis

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Abstract

Impaired mitochondrial biogenesis often results in devastating diseases such as mitochondrial disease, cardiomyopathy, cancer, and metabolic dysfunction. A significant hindrance to understanding these diseases is their genetic and environmental heterogeneity. This work uses unique animal models of mitochondrial dysfunction to investigate the role of a previously uncharacterized protein and its role in the regulation of gene expression in mitochondria. The generation of these animal models provides new systems to investigate tissue specific mitochondrial defects associated with energy dysfunction such as cardiomyopathy and metabolic disease that can be used to develop specific drugs and test treatments to overcome diminishing energy levels.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Filipovska, Aleksandra, Supervisor
  • Azmanov, Dimitar, Supervisor
Thesis sponsors
Award date5 Jun 2019
DOIs
Publication statusUnpublished - 2019

Embargo information

  • Embargoed from 18/06/2019 to 18/06/2021. Made publicly available on 18/06/2021.

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