Understanding the Moderating Role of Cognitive Reserve in Alzheimer’s Disease Using a Residual Approach

Cathryn McKenzie

doi:10.26182/vpmn-wg44

Understanding the Moderating Role of Cognitive Reserve in Alzheimer’s Disease Using a Residual Approach

Cathryn McKenzie

Research output: Thesis › Doctoral Thesis

400 Downloads (Pure)

Abstract

Cognitive reserve is thought to delay cognitive decline in Alzheimer's disease (AD). The residual approach to measuring cognitive reserve operationalises cognitive reserve as the difference between observed memory performance, and the performance expected based on a person's brain health. This thesis further validated the residual approach as a marker of cognitive reserve in AD. The findings of this thesis suggest that cognitive reserve is ‘activated’ as a protective mechanism once a certain degree of AD pathology develops, and that it acts to protect cognition in ageing and AD by influencing neural metabolic efficiency and capacity.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Gavett, Brandon, Supervisor Weinborn, Michael, Supervisor Bucks, Romola, Supervisor Bourgeat, Pierrick, Supervisor, External person Salvado, Olivier, Supervisor, External person
Thesis sponsors	Australian Government Research Training Program
Award date	7 Nov 2022
DOIs	https://doi.org/10.26182/vpmn-wg44
Publication status	Unpublished - 2022

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10.26182/vpmn-wg44

THESIS - DOCTOR OF PHILOSOPHY - McKENZIE, Cathryn - 2022
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Tau and amyloid biomarkers modify the degree to which cognitive reserve and brain reserve predict cognitive decline
The Alzheimer’s Disease Neuroimaging Initiative, McKenzie, C., Bucks, R. S., Weinborn, M., Bourgeat, P., Salvado, O. & Gavett, B. E., 30 Jul 2023, In: Journal of the International Neuropsychological Society. 29, 6, p. 572-581 10 p.
Research output: Contribution to journal › Article › peer-review

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Residual reserve index modifies the effect of amyloid pathology on fluorodeoxyglucose metabolism: Implications for efficiency and capacity in cognitive reserve
McKenzie, C., Bucks, R. S., Weinborn, M., Bourgeat, P., Salvado, O. & Gavett, B. E., 12 Aug 2022, In: Frontiers in Aging Neuroscience. 14, 943823.
Research output: Contribution to journal › Article › peer-review

Open Access
4 Link opens in a new tab Citations (Scopus)
Cognitive reserve predicts future executive function decline in older adults with Alzheimer's disease pathology but not age-associated pathology
McKenzie, C., Bucks, R. S., Weinborn, M., Bourgeat, P., Salvado, O. & Gavett, B. E., Apr 2020, In: Neurobiology of Aging. 88, p. 119-127 9 p.
Research output: Contribution to journal › Article › peer-review

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Cite this

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title = "Understanding the Moderating Role of Cognitive Reserve in Alzheimer{\textquoteright}s Disease Using a Residual Approach",

abstract = "Cognitive reserve is thought to delay cognitive decline in Alzheimer's disease (AD). The residual approach to measuring cognitive reserve operationalises cognitive reserve as the difference between observed memory performance, and the performance expected based on a person's brain health. This thesis further validated the residual approach as a marker of cognitive reserve in AD. The findings of this thesis suggest that cognitive reserve is {\textquoteleft}activated{\textquoteright} as a protective mechanism once a certain degree of AD pathology develops, and that it acts to protect cognition in ageing and AD by influencing neural metabolic efficiency and capacity.",

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AB - Cognitive reserve is thought to delay cognitive decline in Alzheimer's disease (AD). The residual approach to measuring cognitive reserve operationalises cognitive reserve as the difference between observed memory performance, and the performance expected based on a person's brain health. This thesis further validated the residual approach as a marker of cognitive reserve in AD. The findings of this thesis suggest that cognitive reserve is ‘activated’ as a protective mechanism once a certain degree of AD pathology develops, and that it acts to protect cognition in ageing and AD by influencing neural metabolic efficiency and capacity.

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KW - ageing

KW - executive function

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M3 - Doctoral Thesis

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Understanding the Moderating Role of Cognitive Reserve in Alzheimer’s Disease Using a Residual Approach

Abstract

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Research output

Tau and amyloid biomarkers modify the degree to which cognitive reserve and brain reserve predict cognitive decline

Residual reserve index modifies the effect of amyloid pathology on fluorodeoxyglucose metabolism: Implications for efficiency and capacity in cognitive reserve

Cognitive reserve predicts future executive function decline in older adults with Alzheimer's disease pathology but not age-associated pathology

Cite this