Understanding the Moderating Role of Cognitive Reserve in Alzheimer’s Disease Using a Residual Approach

Research output: ThesisDoctoral Thesis

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Abstract

Cognitive reserve is thought to delay cognitive decline in Alzheimer's disease (AD). The residual approach to measuring cognitive reserve operationalises cognitive reserve as the difference between observed memory performance, and the performance expected based on a person's brain health. This thesis further validated the residual approach as a marker of cognitive reserve in AD. The findings of this thesis suggest that cognitive reserve is ‘activated’ as a protective mechanism once a certain degree of AD pathology develops, and that it acts to protect cognition in ageing and AD by influencing neural metabolic efficiency and capacity.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Gavett, Brandon, Supervisor
  • Weinborn, Michael, Supervisor
  • Bucks, Romola, Supervisor
  • Bourgeat, Pierrick, Supervisor, External person
  • Salvado, Olivier, Supervisor, External person
Thesis sponsors
Award date7 Nov 2022
DOIs
Publication statusUnpublished - 2022

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