Understanding the Impact of ZBTB18 Genetic Variation on Neuronal Development and Human Brain Disorder

Isabel Hemming

doi:10.26182/5eb4f20e3e705

Understanding the Impact of ZBTB18 Genetic Variation on Neuronal Development and Human Brain Disorder

Isabel Hemming

UWA Medical School

Research output: Thesis › Doctoral Thesis

998 Downloads (Pure)

Abstract

The development of the cerebral cortex involves the precise generation, positioning, and connectivity of neuronal cells. The activities of DNA-binding transcription factors, such as the zinc finger repressor protein ZBTB18 (aka RP58 or ZNF238), regulate the expression of downstream target genes that facilitate this process. ZBTB18 This on thesis brain aimed to development characterise and the disease. functions for ZBTB18 in cerebral cortex neurons, and the impact of genetic variation in ZBTB18 on brain development and disease. This ZBTB18 thesis has clarified the role of ZBTB18 to influence neuronal development and demonstrates a direct, causative action for

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Forrest, Alistair, Supervisor Heng, Julian, Supervisor Laing, Nigel, Supervisor Agostino, Mark, Supervisor, External person
Thesis sponsors	Australian Government Research Training Program
Award date	9 Mar 2020
DOIs	https://doi.org/10.26182/5eb4f20e3e705
Publication status	Unpublished - 2020

Access to Document

10.26182/5eb4f20e3e705

TH20 59-01 THESIS - DOCTOR OF PHILOSOPHY - HEMMING, Isabel Anne - 2020 - Part 1
TH20 59-02 THESIS - DOCTOR OF PHILOSOPHY - HEMMING, Isabel Anne - 2020 - Part 2
TH20 59-03 THESIS - DOCTOR OF PHILOSOPHY - HEMMING, Isabel Anne - 2020 - Part 3
This work is protected by Copyright. You may print or download ONE copy of this document for the purpose of your own non-commercial research or study. Any other use requires permission from the copyright owner. The Copyright Act requires you to attribute any copyright works you quote or paraphrase.

Cite this

@phdthesis{e5919cb5d0104f7dab7e1160fc500742,

title = "Understanding the Impact of ZBTB18 Genetic Variation on Neuronal Development and Human Brain Disorder",

abstract = "The development of the cerebral cortex involves the precise generation, positioning, and connectivity of neuronal cells. The activities of DNA-binding transcription factors, such as the zinc finger repressor protein ZBTB18 (aka RP58 or ZNF238), regulate the expression of downstream target genes that facilitate this process. ZBTB18 This on thesis brain aimed to development characterise and the disease. functions for ZBTB18 in cerebral cortex neurons, and the impact of genetic variation in ZBTB18 on brain development and disease. This ZBTB18 thesis has clarified the role of ZBTB18 to influence neuronal development and demonstrates a direct, causative action for",

keywords = "Neuroscience, Nervous System Disease, Genetics, Biochemistry and Cell Biology, ZBT818,RP58,ZNF238",

author = "Isabel Hemming",

year = "2020",

doi = "10.26182/5eb4f20e3e705",

language = "English",

school = "The University of Western Australia",

}

TY - THES

T1 - Understanding the Impact of ZBTB18 Genetic Variation on Neuronal Development and Human Brain Disorder

AU - Hemming, Isabel

PY - 2020

Y1 - 2020

N2 - The development of the cerebral cortex involves the precise generation, positioning, and connectivity of neuronal cells. The activities of DNA-binding transcription factors, such as the zinc finger repressor protein ZBTB18 (aka RP58 or ZNF238), regulate the expression of downstream target genes that facilitate this process. ZBTB18 This on thesis brain aimed to development characterise and the disease. functions for ZBTB18 in cerebral cortex neurons, and the impact of genetic variation in ZBTB18 on brain development and disease. This ZBTB18 thesis has clarified the role of ZBTB18 to influence neuronal development and demonstrates a direct, causative action for

AB - The development of the cerebral cortex involves the precise generation, positioning, and connectivity of neuronal cells. The activities of DNA-binding transcription factors, such as the zinc finger repressor protein ZBTB18 (aka RP58 or ZNF238), regulate the expression of downstream target genes that facilitate this process. ZBTB18 This on thesis brain aimed to development characterise and the disease. functions for ZBTB18 in cerebral cortex neurons, and the impact of genetic variation in ZBTB18 on brain development and disease. This ZBTB18 thesis has clarified the role of ZBTB18 to influence neuronal development and demonstrates a direct, causative action for

KW - Neuroscience

KW - Nervous System Disease

KW - Genetics

KW - Biochemistry and Cell Biology

KW - ZBT818,RP58,ZNF238

U2 - 10.26182/5eb4f20e3e705

DO - 10.26182/5eb4f20e3e705

M3 - Doctoral Thesis

ER -

Understanding the Impact of ZBTB18 Genetic Variation on Neuronal Development and Human Brain Disorder

Abstract

Access to Document

Fingerprint

Cite this