Understanding the Impact of ZBTB18 Genetic Variation on Neuronal Development and Human Brain Disorder

Isabel Hemming

Research output: ThesisDoctoral Thesis

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Abstract

The development of the cerebral cortex involves the precise generation, positioning, and connectivity of neuronal cells. The activities of DNA-binding transcription factors, such as the zinc finger repressor protein ZBTB18 (aka RP58 or ZNF238), regulate the expression of downstream target genes that facilitate this process. ZBTB18 This on thesis brain aimed to development characterise and the disease. functions for ZBTB18 in cerebral cortex neurons, and the impact of genetic variation in ZBTB18 on brain development and disease. This ZBTB18 thesis has clarified the role of ZBTB18 to influence neuronal development and demonstrates a direct, causative action for
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Forrest, Alistair, Supervisor
  • Heng, Julian, Supervisor
  • Laing, Nigel, Supervisor
  • Agostino, Mark, Supervisor, External person
Thesis sponsors
Award date9 Mar 2020
DOIs
Publication statusUnpublished - 2020

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