Understanding protein glycosylation pathways in bacteria

Hong Li, Aleksandra W. Debowski, Tingting Liao, Hong Tang, Hans-Olof Nilsson, Barry J. Marshall, Keith A. Stubbs, Mohammed Benghezal

Research output: Contribution to journalReview article

10 Citations (Scopus)
718 Downloads (Pure)

Abstract

Through advances in analytical methods to detect glycoproteins and to determine glycan structures, there have been increasing reports of protein glycosylation in bacteria. In this review, we summarize the known pathways for bacterial protein glycosylation: lipid carrier-mediated 'en bloc' glycosylation; and cytoplasmic stepwise protein glycosylation. The exploitation of bacterial protein glycosylation systems, especially the 'mix and match' of three independent but similar pathways (oligosaccharyltransferase-mediated protein glycosylation, lipopolysaccharide and peptidoglycan biosynthesis) in Gram-negative bacteria for glycoengineering recombinant glycoproteins is also discussed.

Original languageEnglish
Pages (from-to)59-72
Number of pages14
JournalFuture Microbiology
Volume12
Issue number1
DOIs
Publication statusPublished - 1 Jan 2017

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