Understanding how plant asparaginyl endopeptidases perform cleavage and transpeptidation

Samuel Nonis

Research output: ThesisDoctoral Thesis

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Abstract

This thesis details the structural and biochemical investigation of a family of versatile plant enzymes, called asparaginyl endopeptidases, and the unique circular permutation of a widely used but incompletely understood reagent, concanavalin A. The published works reveal the inner workings of these molecular machinery, contributing not only to a burgeoning field of study, where scientists hope to harness the biotechnological potential of a recently discovered group of super-efficient enzymes, but also to areas of study that begun more than a century ago, where decades-old assumptions are, here, finally proven to be wrong.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Mylne, Josh, Supervisor
  • Bond, Charlie, Supervisor
Thesis sponsors
Award date22 Nov 2021
DOIs
Publication statusUnpublished - 2021

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