Abstract
Obesity is increasing in prevalence in many countries around the world. Its causes have been traditionally ascribed to a model where energy intake exceeds energy consumption. Reduced energy output in the form of exercise is associated with less sun exposure as many of these activities occur outdoors. This review explores the potential for ultraviolet radiation (UVR), derived from sun exposure, to affect the development of obesity and two of its metabolic co-morbidities, type-2 diabetes and metabolic syndrome. We here discuss the potential benefits (or otherwise) of exposure to UVR based on evidence from pre-clinical, human epidemiological and clinical studies and explore and compare the potential role of UVR-induced mediators, including vitamin D and nitric oxide. Overall, emerging findings suggest a protective role for UVR and sun exposure in reducing the development of obesity and cardiometabolic dysfunction, but more epidemiological and clinical research is required that focuses on measuring the direct associations and effects of exposure to UVR in humans.
| Original language | English |
|---|---|
| Pages (from-to) | 362-373 |
| Number of pages | 12 |
| Journal | Photochemical and Photobiological Sciences |
| Volume | 16 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2017 |
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Ultraviolet radiation, Vitamin D and the development of obesity, metabolic syndrome and type-2 diabetes. / Gorman, Shelley; Lucas, Robyn M.; Allen-Hall, Aidan; Fleury, Naomi; Feelisch, Martin.
In: Photochemical and Photobiological Sciences, Vol. 16, No. 3, 2017, p. 362-373.Research output: Contribution to journal › Article
TY - JOUR
T1 - Ultraviolet radiation, Vitamin D and the development of obesity, metabolic syndrome and type-2 diabetes
AU - Gorman, Shelley
AU - Lucas, Robyn M.
AU - Allen-Hall, Aidan
AU - Fleury, Naomi
AU - Feelisch, Martin
PY - 2017
Y1 - 2017
N2 - Obesity is increasing in prevalence in many countries around the world. Its causes have been traditionally ascribed to a model where energy intake exceeds energy consumption. Reduced energy output in the form of exercise is associated with less sun exposure as many of these activities occur outdoors. This review explores the potential for ultraviolet radiation (UVR), derived from sun exposure, to affect the development of obesity and two of its metabolic co-morbidities, type-2 diabetes and metabolic syndrome. We here discuss the potential benefits (or otherwise) of exposure to UVR based on evidence from pre-clinical, human epidemiological and clinical studies and explore and compare the potential role of UVR-induced mediators, including vitamin D and nitric oxide. Overall, emerging findings suggest a protective role for UVR and sun exposure in reducing the development of obesity and cardiometabolic dysfunction, but more epidemiological and clinical research is required that focuses on measuring the direct associations and effects of exposure to UVR in humans.
AB - Obesity is increasing in prevalence in many countries around the world. Its causes have been traditionally ascribed to a model where energy intake exceeds energy consumption. Reduced energy output in the form of exercise is associated with less sun exposure as many of these activities occur outdoors. This review explores the potential for ultraviolet radiation (UVR), derived from sun exposure, to affect the development of obesity and two of its metabolic co-morbidities, type-2 diabetes and metabolic syndrome. We here discuss the potential benefits (or otherwise) of exposure to UVR based on evidence from pre-clinical, human epidemiological and clinical studies and explore and compare the potential role of UVR-induced mediators, including vitamin D and nitric oxide. Overall, emerging findings suggest a protective role for UVR and sun exposure in reducing the development of obesity and cardiometabolic dysfunction, but more epidemiological and clinical research is required that focuses on measuring the direct associations and effects of exposure to UVR in humans.
UR - http://www.scopus.com/inward/record.url?scp=85015680378&partnerID=8YFLogxK
U2 - 10.1039/C6PP00274A
DO - 10.1039/C6PP00274A
M3 - Article
VL - 16
SP - 362
EP - 373
JO - PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
JF - PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
SN - 1474-905X
IS - 3
ER -