Ultraviolet radiation, Vitamin D and the development of obesity, metabolic syndrome and type-2 diabetes

Shelley Gorman, Robyn M. Lucas, Aidan Allen-Hall, Naomi Fleury, Martin Feelisch

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Obesity is increasing in prevalence in many countries around the world. Its causes have been traditionally ascribed to a model where energy intake exceeds energy consumption. Reduced energy output in the form of exercise is associated with less sun exposure as many of these activities occur outdoors. This review explores the potential for ultraviolet radiation (UVR), derived from sun exposure, to affect the development of obesity and two of its metabolic co-morbidities, type-2 diabetes and metabolic syndrome. We here discuss the potential benefits (or otherwise) of exposure to UVR based on evidence from pre-clinical, human epidemiological and clinical studies and explore and compare the potential role of UVR-induced mediators, including vitamin D and nitric oxide. Overall, emerging findings suggest a protective role for UVR and sun exposure in reducing the development of obesity and cardiometabolic dysfunction, but more epidemiological and clinical research is required that focuses on measuring the direct associations and effects of exposure to UVR in humans.

Original languageEnglish
Pages (from-to)362-373
Number of pages12
JournalPhotochemical and Photobiological Sciences
Volume16
Issue number3
DOIs
Publication statusPublished - 2017

Fingerprint

calciferol
obesity
Medical problems
Vitamin D
Ultraviolet radiation
ultraviolet radiation
Sun
sun
energy consumption
physical exercise
nitric oxide
emerging
Nitric Oxide
Energy utilization
oxides
energy
causes
output

Cite this

Gorman, Shelley ; Lucas, Robyn M. ; Allen-Hall, Aidan ; Fleury, Naomi ; Feelisch, Martin. / Ultraviolet radiation, Vitamin D and the development of obesity, metabolic syndrome and type-2 diabetes. In: Photochemical and Photobiological Sciences. 2017 ; Vol. 16, No. 3. pp. 362-373.
@article{2d3ce9d71db54e0894ce2e690fd17961,
title = "Ultraviolet radiation, Vitamin D and the development of obesity, metabolic syndrome and type-2 diabetes",
abstract = "Obesity is increasing in prevalence in many countries around the world. Its causes have been traditionally ascribed to a model where energy intake exceeds energy consumption. Reduced energy output in the form of exercise is associated with less sun exposure as many of these activities occur outdoors. This review explores the potential for ultraviolet radiation (UVR), derived from sun exposure, to affect the development of obesity and two of its metabolic co-morbidities, type-2 diabetes and metabolic syndrome. We here discuss the potential benefits (or otherwise) of exposure to UVR based on evidence from pre-clinical, human epidemiological and clinical studies and explore and compare the potential role of UVR-induced mediators, including vitamin D and nitric oxide. Overall, emerging findings suggest a protective role for UVR and sun exposure in reducing the development of obesity and cardiometabolic dysfunction, but more epidemiological and clinical research is required that focuses on measuring the direct associations and effects of exposure to UVR in humans.",
author = "Shelley Gorman and Lucas, {Robyn M.} and Aidan Allen-Hall and Naomi Fleury and Martin Feelisch",
year = "2017",
doi = "10.1039/C6PP00274A",
language = "English",
volume = "16",
pages = "362--373",
journal = "PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES",
issn = "1474-905X",
publisher = "ROYAL SOC CHEMISTRY",
number = "3",

}

Ultraviolet radiation, Vitamin D and the development of obesity, metabolic syndrome and type-2 diabetes. / Gorman, Shelley; Lucas, Robyn M.; Allen-Hall, Aidan; Fleury, Naomi; Feelisch, Martin.

In: Photochemical and Photobiological Sciences, Vol. 16, No. 3, 2017, p. 362-373.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Ultraviolet radiation, Vitamin D and the development of obesity, metabolic syndrome and type-2 diabetes

AU - Gorman, Shelley

AU - Lucas, Robyn M.

AU - Allen-Hall, Aidan

AU - Fleury, Naomi

AU - Feelisch, Martin

PY - 2017

Y1 - 2017

N2 - Obesity is increasing in prevalence in many countries around the world. Its causes have been traditionally ascribed to a model where energy intake exceeds energy consumption. Reduced energy output in the form of exercise is associated with less sun exposure as many of these activities occur outdoors. This review explores the potential for ultraviolet radiation (UVR), derived from sun exposure, to affect the development of obesity and two of its metabolic co-morbidities, type-2 diabetes and metabolic syndrome. We here discuss the potential benefits (or otherwise) of exposure to UVR based on evidence from pre-clinical, human epidemiological and clinical studies and explore and compare the potential role of UVR-induced mediators, including vitamin D and nitric oxide. Overall, emerging findings suggest a protective role for UVR and sun exposure in reducing the development of obesity and cardiometabolic dysfunction, but more epidemiological and clinical research is required that focuses on measuring the direct associations and effects of exposure to UVR in humans.

AB - Obesity is increasing in prevalence in many countries around the world. Its causes have been traditionally ascribed to a model where energy intake exceeds energy consumption. Reduced energy output in the form of exercise is associated with less sun exposure as many of these activities occur outdoors. This review explores the potential for ultraviolet radiation (UVR), derived from sun exposure, to affect the development of obesity and two of its metabolic co-morbidities, type-2 diabetes and metabolic syndrome. We here discuss the potential benefits (or otherwise) of exposure to UVR based on evidence from pre-clinical, human epidemiological and clinical studies and explore and compare the potential role of UVR-induced mediators, including vitamin D and nitric oxide. Overall, emerging findings suggest a protective role for UVR and sun exposure in reducing the development of obesity and cardiometabolic dysfunction, but more epidemiological and clinical research is required that focuses on measuring the direct associations and effects of exposure to UVR in humans.

UR - http://www.scopus.com/inward/record.url?scp=85015680378&partnerID=8YFLogxK

U2 - 10.1039/C6PP00274A

DO - 10.1039/C6PP00274A

M3 - Article

VL - 16

SP - 362

EP - 373

JO - PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

JF - PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

SN - 1474-905X

IS - 3

ER -