Ultraviolet radiation, vitamin D and multiple sclerosis

Robyn M. Lucas, Scott N. Byrne, Jorge Correale, Susanne Ilschner, Prue H. Hart

Research output: Contribution to journalReview article

44 Citations (Scopus)

Abstract

There is compelling epidemiological evidence that the risk of developing multiple sclerosis is increased in association with low levels of sun exposure, possibly because this is associated with low vitamin D status. Recent work highlights both vitamin D and non-vitamin D effects on cellular immunity that suggests that higher levels of sun exposure and/or vitamin D status are beneficial for both MS risk and in ameliorating disease progression. Here we review this recent evidence, focusing on regulatory cells, dendritic cells, and chemokines and cytokines released from the skin following exposure to ultraviolet radiation.

Original languageEnglish
Pages (from-to)413-424
Number of pages12
JournalNeurodegenerative Disease Management
Volume5
Issue number5
DOIs
Publication statusPublished - 1 Oct 2015

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