Ultrasound characterization of medial gastrocnemius composition in children with spastic cereral palsy.

Christian Pitcher, Catherine Elliott, Fausto Panizzolo, Jane Valentine, K. Stannage, Siobhan Reid

    Research output: Contribution to journalArticle

    22 Citations (Scopus)

    Abstract

    © 2015 Wiley Periodicals, Inc. Introduction: In this study we aimed to characterize muscle composition of the medial gastrocnemius in children with spastic cerebral palsy (SCP) using quantitative ultrasound. Methods: Forty children with SCP, aged 4-14 years, participated in this study. Children were grouped according to the gross motor function classification system (GMFCS I-V) and compared with a cohort of age- and gender-matched, typically developing children (TD; n=12). Ultrasound scans were taken of the medial gastrocnemius. Images were then characterized using grayscale statistics to determine mean echo intensity (EI) and the size and number of spatially connected homogeneous regions (i.e., blobs). Results: Significant differences in skeletal muscle composition were found between children with SCP and their TD peers. Children classified as GMFCS III consistently exhibited the highest EI and blob area. Conclusions: This study demonstrates altered tissue composition in children with SCP visualized using ultrasound. Further work is required to determine the pathophysiology contributing to these alterations in SCP.
    Original languageEnglish
    Pages (from-to)397-403
    JournalMuscle and Nerve
    Volume52
    Issue number3
    DOIs
    Publication statusPublished - 2014

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    Muscle Spasticity
    Paralysis
    Cerebral Palsy
    Skeletal Muscle
    Muscles

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    @article{9b2adc289be7485fa597f99a048ed69b,
    title = "Ultrasound characterization of medial gastrocnemius composition in children with spastic cereral palsy.",
    abstract = "{\circledC} 2015 Wiley Periodicals, Inc. Introduction: In this study we aimed to characterize muscle composition of the medial gastrocnemius in children with spastic cerebral palsy (SCP) using quantitative ultrasound. Methods: Forty children with SCP, aged 4-14 years, participated in this study. Children were grouped according to the gross motor function classification system (GMFCS I-V) and compared with a cohort of age- and gender-matched, typically developing children (TD; n=12). Ultrasound scans were taken of the medial gastrocnemius. Images were then characterized using grayscale statistics to determine mean echo intensity (EI) and the size and number of spatially connected homogeneous regions (i.e., blobs). Results: Significant differences in skeletal muscle composition were found between children with SCP and their TD peers. Children classified as GMFCS III consistently exhibited the highest EI and blob area. Conclusions: This study demonstrates altered tissue composition in children with SCP visualized using ultrasound. Further work is required to determine the pathophysiology contributing to these alterations in SCP.",
    author = "Christian Pitcher and Catherine Elliott and Fausto Panizzolo and Jane Valentine and K. Stannage and Siobhan Reid",
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    Ultrasound characterization of medial gastrocnemius composition in children with spastic cereral palsy. / Pitcher, Christian; Elliott, Catherine; Panizzolo, Fausto; Valentine, Jane; Stannage, K.; Reid, Siobhan.

    In: Muscle and Nerve, Vol. 52, No. 3, 2014, p. 397-403.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Ultrasound characterization of medial gastrocnemius composition in children with spastic cereral palsy.

    AU - Pitcher, Christian

    AU - Elliott, Catherine

    AU - Panizzolo, Fausto

    AU - Valentine, Jane

    AU - Stannage, K.

    AU - Reid, Siobhan

    PY - 2014

    Y1 - 2014

    N2 - © 2015 Wiley Periodicals, Inc. Introduction: In this study we aimed to characterize muscle composition of the medial gastrocnemius in children with spastic cerebral palsy (SCP) using quantitative ultrasound. Methods: Forty children with SCP, aged 4-14 years, participated in this study. Children were grouped according to the gross motor function classification system (GMFCS I-V) and compared with a cohort of age- and gender-matched, typically developing children (TD; n=12). Ultrasound scans were taken of the medial gastrocnemius. Images were then characterized using grayscale statistics to determine mean echo intensity (EI) and the size and number of spatially connected homogeneous regions (i.e., blobs). Results: Significant differences in skeletal muscle composition were found between children with SCP and their TD peers. Children classified as GMFCS III consistently exhibited the highest EI and blob area. Conclusions: This study demonstrates altered tissue composition in children with SCP visualized using ultrasound. Further work is required to determine the pathophysiology contributing to these alterations in SCP.

    AB - © 2015 Wiley Periodicals, Inc. Introduction: In this study we aimed to characterize muscle composition of the medial gastrocnemius in children with spastic cerebral palsy (SCP) using quantitative ultrasound. Methods: Forty children with SCP, aged 4-14 years, participated in this study. Children were grouped according to the gross motor function classification system (GMFCS I-V) and compared with a cohort of age- and gender-matched, typically developing children (TD; n=12). Ultrasound scans were taken of the medial gastrocnemius. Images were then characterized using grayscale statistics to determine mean echo intensity (EI) and the size and number of spatially connected homogeneous regions (i.e., blobs). Results: Significant differences in skeletal muscle composition were found between children with SCP and their TD peers. Children classified as GMFCS III consistently exhibited the highest EI and blob area. Conclusions: This study demonstrates altered tissue composition in children with SCP visualized using ultrasound. Further work is required to determine the pathophysiology contributing to these alterations in SCP.

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