Ultrahigh-resolution optical coherence elastography

Andrea Curatolo, M. Villiger, Dirk Lorenser, Philip Wijesinghe, A. Fritz, Brendan Kennedy, David Sampson

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Abstract

Visualizing stiffness within the local tissue environment at the cellular and subcellular level promises to provide insight into the genesis and progression of disease. In this Letter, we propose ultrahigh-resolution optical coherence elastography (UHROCE), and demonstrate 3D imaging of local axial strain of tissues undergoing compressive loading. We combine optical coherence microscopy (OCM) and phase-sensitive detection of local tissue displacement to produce strain elastograms with resolution (x,y,z) of 2×2×15  μm . We demonstrate this performance on a freshly excised mouse aorta and reveal the mechanical heterogeneity of vascular smooth muscle cells and elastin sheets, otherwise unresolved in a typical, lower resolution optical coherence elastography (OCE) system.
Original languageEnglish
Pages (from-to)21-24
JournalOptics Letters
Volume41
Issue number1
Early online date16 Dec 2015
DOIs
Publication statusPublished - 1 Jan 2016

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elastin
smooth muscle
muscle cells
aorta
axial strain
progressions
mice
stiffness
microscopy

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Curatolo, Andrea ; Villiger, M. ; Lorenser, Dirk ; Wijesinghe, Philip ; Fritz, A. ; Kennedy, Brendan ; Sampson, David. / Ultrahigh-resolution optical coherence elastography. In: Optics Letters. 2016 ; Vol. 41, No. 1. pp. 21-24.
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Ultrahigh-resolution optical coherence elastography. / Curatolo, Andrea; Villiger, M.; Lorenser, Dirk; Wijesinghe, Philip; Fritz, A.; Kennedy, Brendan; Sampson, David.

In: Optics Letters, Vol. 41, No. 1, 01.01.2016, p. 21-24.

Research output: Contribution to journalArticle

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AU - Sampson, David

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Curatolo A, Villiger M, Lorenser D, Wijesinghe P, Fritz A, Kennedy B et al. Ultrahigh-resolution optical coherence elastography. Optics Letters. 2016 Jan 1;41(1):21-24. https://doi.org/10.1364/OL.41.000021