Ultra-high resolution polarization-sensitive optical coherence tomography for imaging of the retinal nerve fiber layer

Barry Cense, Maddipatla Reddikumar, Joel Cervantes

Research output: Chapter in Book/Conference paperConference paper

2 Citations (Scopus)

Abstract

A spectrometer design with a multiple line line-scan camera and beam displacer is presented for ultra-high resolution optical coherence tomography measurements of the human retina at 840 nm. The beam displacer offsets the two orthogonal polarization states on the same line-scan camera, which reduces k-space mapping complexity, as data in both polarization channels can be mapped with the same procedure. Its coherence length is 2.8 mu m in tissue (n = 1.38). Birefringence values of 1 degrees/mu m and higher were found in a circle with a radius of 2.5 degrees eccentricity centered on the fovea, and in the raphe, pointing at a higher packing density of microtubules and a lower concentration of glia. Birefringence measurements may be more helpful in the modeling of individual structure-function maps than thickness measurements, as they are not affected by glial content.

Original languageEnglish
Title of host publicationProceedings of the Biomedical Imaging and Sensing Conference
EditorsT Yatagai, Y Aizu, O Matoba, Y Awatsuji
Place of PublicationJapan
PublisherSPIE-INT SOC OPTICAL ENGINEERING
Number of pages3
Volume10251
ISBN (Print)9781510610040
DOIs
Publication statusPublished - 2017
Externally publishedYes
Event3rd Biomedical Imaging and Sensing Conference - Yokohama, Japan
Duration: 19 Apr 201721 Apr 2017

Publication series

NameProceedings of SPIE
PublisherSPIE-INT SOC OPTICAL ENGINEERING
Volume10251
ISSN (Print)0277-786X

Conference

Conference3rd Biomedical Imaging and Sensing Conference
CountryJapan
CityYokohama
Period19/04/1721/04/17

Cite this

Cense, B., Reddikumar, M., & Cervantes, J. (2017). Ultra-high resolution polarization-sensitive optical coherence tomography for imaging of the retinal nerve fiber layer. In T. Yatagai, Y. Aizu, O. Matoba, & Y. Awatsuji (Eds.), Proceedings of the Biomedical Imaging and Sensing Conference (Vol. 10251). (Proceedings of SPIE; Vol. 10251). SPIE-INT SOC OPTICAL ENGINEERING. https://doi.org/10.1117/12.2275020