Type 2 (subretinal) neovascularization in agerelated macular degeneration associated with pure reticular pseudodrusen phenotype

Jonathan Naysan, Jesse J Jung, Kunal K Dansingani, Chandrakumar Balaratnasingam, K Bailey Freund

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

PURPOSE: To report the association of pure type 2 neovascularization (NV) in age-related macular degeneration occurring almost exclusively in patients with reticular pseudodrusen.

METHODS: An observational retrospective cohort study of all eyes receiving antivascular endothelial growth factor therapy for newly diagnosed neovascular age-related macular degeneration by a single practitioner over a 6-year period. Only patients with treatment-naive, pure type 2 NV who also had either pre-neovascular imaging of the study eye or imaging of a nonneovascular fellow eye available to determine baseline characteristics including drusen type and choroidal thickness were incuded.

RESULTS: Of 694 patients treated for neovascular age-related macular degeneration, only 8 met the inclusion criteria with pure type 2 NV. Of these, 7 (88%) had exclusively reticular pseudodrusen (5 in the nonneovascular fellow eye, 2 in the study eye before developing NV). Six (75%) patients in the affected neovascular eye and 6 (75%) in the fellow nonneovascular eye had choroidal thickness <120 μm. Mean follow-up was 46 months (range, 3.0-63.3). Best-corrected vision improved from 20/89 (range, 20/30-20/796) at baseline to 20/60 (range, 20/20-20/399) at last follow-up.

CONCLUSION: Pure type 2 NV is rare in age-related macular degeneration, occurring almost exclusively in patients with reticular pseudodrusen and thin choroids.

Original languageEnglish
Pages (from-to)449-457
Number of pages9
JournalRetina (Philadelphia, Pa.)
Volume36
Issue number3
DOIs
Publication statusPublished - Mar 2016
Externally publishedYes

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