@article{0fc65b93e62246949aa8759439f6cedf,
title = "Type 1 diabetes: a disease of developmental origins",
abstract = "The incidence of type 1 diabetes globally has increased dramatically over the last 50 years. Proposed environmental reasons for this increase mirror the modern lifestyle. Type 1 diabetes can be viewed as part of the non- communicable disease epidemic in our modern society. Meanwhile rapidly evolving new technologies are advancing our understanding of how human microbial communities interface with the immune system and metabolism, and how the modern pro-inflammatory environment is changing these communities and contributing to the rapid rise of non-communicable disease. The majority of children who present with clinical type 1 diabetes are of school age; however 80% of children who develop type 1 diabetes by 18 years of age will have detectable islet autoantibodies by 3 years of age. The evolving concept that type 1 diabetes in many children has developmental origins has directed research questions in search of prevention back to pregnancy and early life. To this end the world's first pregnancy to early childhood cohort study in at-risk children has commenced.",
keywords = "developmental origins of health and disease, epigenetics, microbiome",
author = "{ENDIA Study Group} and Phillips, {Jessica E.} and Couper, {Jennifer J.} and Penno, {Megan A.S.} and Harrison, {Leonard C.} and Heather Anderson and Esther Bandala-Sanchez and Barry, {Simon C.} and Tracey Baskerville and Rachel Battersby and Bediaga, {Naiara G.} and Debra Bezuidenhout and Emma Brownrigg and Jacki Catteau and Ace Choo and Colman, {Peter G.} and Andrew Cotterill and Craig, {Maria E.} and Sheryl Curran and Davis, {Elizabeth A.} and Dodd, {Jodie M.} and Danielle Edwards and Jane French and Emily Gibson and Giles, {Lynne C.} and Alison Gwiazdzinski and Mark Harris and Aveni Haynes and Hope, {Christopher M.} and Cecilia Hsieh and Dexing Huang and William Hu and Azita Keytash and Meredith Krieg and Law, {Soi C.} and Catherine Lloyd-Johnsen and Grant Morahan and Neale, {Alana M.} and Katrina Ngui and Papenfuss, {Anthony T.} and Megan Poth and Benjamin Ramoso and Rawlinson, {William D.} and Alison Roberts and Sadlon, {Timothy J.} and Alexandra Schulze and Penington, {Jocelyn Sietsma} and Sinnott, {Richard O.} and Kelly Spooner and Stone, {Natalie L.} and Thomson, {Rebecca L.} and Sarah Toome and Alexandra Tully and Vuillermin, {Peter J.} and Kelly Watson and Wentworth, {John M.} and Julianne Wilson",
year = "2017",
month = sep,
doi = "10.1111/pedi.12425",
language = "English",
volume = "18",
pages = "417--421",
journal = "Pediatric Diabetes",
issn = "1399-543X",
publisher = "John Wiley & Sons",
number = "6",
}