Tunable Biodegradable Silk-Based Memory Foams with Controlled Release of Antibiotics

Laura Chambre, Rachael N. Parker, Benjamin J. Allardyce, Filippo Valente, Rangam Rajkhowa, Rodney J. Dilley, Xungai Wang, David L. Kaplan

    Research output: Contribution to journalArticlepeer-review

    10 Citations (Web of Science)

    Abstract

    Sustained, local delivery of the antibiotic ciprofloxacin under different formats from porous silk protein-based memory foam systems was studied. Similarly, protease XIV was incorporated during processing to provide control of the degradation kinetics of the silk materials. In vitro antibiotic release studies combined with degradation assessments were utilized to assess the mechanisms and kinetics of release from the silk materials. The sequestered protease XIV affected the degradation profiles of the silk foams yet did not impact the release kinetics of the ciprofloxacin, which was controlled by solubility and diffusion of the drug. The ability to tune the release of ciprofloxacin between 1 and 200 days, combined with the option to modulate the degradation rate up to 80% in 2 weeks via incorporation of a protease, suggests utility for drug release devices. Further, we anticipate that this approach could also be extended to other medical implant needs and other drugs.

    Original languageEnglish
    Pages (from-to)2466-2472
    Number of pages7
    JournalACS Applied Bio Materials
    Volume3
    Issue number4
    DOIs
    Publication statusPublished - 20 Apr 2020

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