Tumour-derived extracellular vesicles (EV) – a real time functional assessment of tumour activity in patients with head and neck cancer (HNC)

Bella Nguyen

Research output: ThesisDoctoral Thesis

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Abstract

Head and neck cancer (HNC) is a common cancer, with high patient morbidity and mortality. Standard methods of diagnosis and disease monitoring remain limited to invasive tumoural biopsy and serial imaging. My PhD project plans to perform comprehensive assessments of tumor-derived extracellular vesicles (EVs) and their potential as a novel biomarker in HNC patients on treatment. I will systematically and comprehensively analyse tumor-derived EVs levels, sizes, concentrations, and content of associated DNA, RNA, and characterise immune profiles to explore the utility of EV as a non-invasive source of tumour material for molecular assessment in serum from patients on therapy.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Millward, Michael, Supervisor
  • Lim, Annette, Supervisor
  • Meehan, Katie, Supervisor
  • Fuller, Kathy, Supervisor
Thesis sponsors
Award date13 Oct 2023
DOIs
Publication statusUnpublished - 2023

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