Tumor growth or regression : powered by inflammation

D. Nelson, Ruth Ganss

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Malignant cells thrive in a highly specialized, stromal environment, which harbors support cells, blood vessels, and diverse leukocyte populations. There is increasing evidence that "by default", intratumoral inflammation fosters angiogenic and vasculogenic processes and simultaneously creates an immunosuppressive micromilieu. This self-amplifying loop of proangiogenic inflammation represents a serious obstacle for adaptive anticancer immune responses. However, angiogenesis is a highly dynamic process, which can be reversed in the "right" inflammatory context; this in turn facilitates immune effector cell entry and tumor rejection. Thus, we propose that a shift from proangiogenic to antiangiogenic inflammation creates a tumor environment permissive for immune destruction. This is a new concept, which integrates antiangiogenic and immune therapeutic treatment modalities. J. Leukoc. Biol. 80: 685-690;2006.
Original languageEnglish
Pages (from-to)685-690
JournalJournal of Leukocyte Biology
Volume80
Issue number4
DOIs
Publication statusPublished - 2006

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