TY - JOUR
T1 - Tuberculosis-associated immune reconstitution inflammatory syndrome: case definitions for use in resource-limited settings
AU - Meintjes, G.
AU - Lawn, S.D.
AU - Scano, F.
AU - Maartens, G.
AU - French, Martyn
AU - Worodria, W.
AU - Elliott, J.H.
AU - Murdoch, D.
AU - Wilkinson, R.J.
AU - Seyler, C.
AU - John, L.
AU - Van Der Loeff, M.S.
AU - Reiss, P.
AU - Lynen, L.
AU - Janoff, E.N.
AU - Gilks, C.
AU - Colebunders, R.
PY - 2008
Y1 - 2008
N2 - The immune reconstitution inflammatory syndrome (IRIS) has emerged as an important early complication of antiretroviral therapy (ART) in resource-limited settings, especially in patients with tuberculosis. However, there are no consensus case definitions for IRIS or tuberculosis-associated IRIS. Moreover, previously proposed case definitions are not readily applicable in settings where laboratory resources are limited. As a result, existing studies on tuberculosis-associated IRIS have used a variety of non-standardised general case definitions. To rectify this problem, around 100 researchers, including microbiologists, immunologists, clinicians, epidemiologists, clinical trialists, and public-health specialists from 16 countries met in Kampala, Uganda, in November, 2006. At this meeting, consensus case definitions for paradoxical tuberculosis-associated IRIS, ART-associated tuberculosis, and unmasking tuberculosis-associated IRIS were derived, which can be used in high-income and resource-limited settings. It is envisaged that these definitions could be used by clinicians and researchers in a variety of settings to promote standardisation and comparability of data.
AB - The immune reconstitution inflammatory syndrome (IRIS) has emerged as an important early complication of antiretroviral therapy (ART) in resource-limited settings, especially in patients with tuberculosis. However, there are no consensus case definitions for IRIS or tuberculosis-associated IRIS. Moreover, previously proposed case definitions are not readily applicable in settings where laboratory resources are limited. As a result, existing studies on tuberculosis-associated IRIS have used a variety of non-standardised general case definitions. To rectify this problem, around 100 researchers, including microbiologists, immunologists, clinicians, epidemiologists, clinical trialists, and public-health specialists from 16 countries met in Kampala, Uganda, in November, 2006. At this meeting, consensus case definitions for paradoxical tuberculosis-associated IRIS, ART-associated tuberculosis, and unmasking tuberculosis-associated IRIS were derived, which can be used in high-income and resource-limited settings. It is envisaged that these definitions could be used by clinicians and researchers in a variety of settings to promote standardisation and comparability of data.
U2 - 10.1016/S1473-3099(08)70184-1
DO - 10.1016/S1473-3099(08)70184-1
M3 - Article
VL - 8
SP - 516
EP - 523
JO - The Lancet Infectious Diseases
JF - The Lancet Infectious Diseases
SN - 1473-3099
IS - 8
ER -