Triazoles and other N-Containing metabolites from the marine-derived endophytic fungus penicillium chrysogenum EN-118

Chun Yan An, Xiao Ming Li, Chun Shun Li, Shu Shan Gao, Zhuo Shang, Bin Gui Wang

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Two new triazoles, chrysotriazoles A and B (1 and 2, resp.), along with two known quinazolinones, 3 and 4, two known 2-(4-hydroxyphenyl)acetamides, 5 and 6, and two known N-(4-hydroxystyryl)formamides, 7 and 8, were isolated and identified from the culture extract of Penicillium chrysogenum EN-118, an endophytic fungus obtained from the marine brown alga Sargassum pallidium. The structures of the isolated compounds were elucidated by NMR-spectroscopic analysis, and that of compound 1 was confirmed by X-ray crystallographic analysis of its p-bromobenzoate derivative. Compounds 4, 5, and 7 showed moderate cytotoxicities against Du145, A-549, and HeLa cell lines.

Original languageEnglish
Pages (from-to)682-687
Number of pages6
JournalHelvetica Chimica Acta
Volume96
Issue number4
DOIs
Publication statusPublished - Apr 2013
Externally publishedYes

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