TY - JOUR
T1 - Triazoles and other N-Containing metabolites from the marine-derived endophytic fungus penicillium chrysogenum EN-118
AU - An, Chun Yan
AU - Li, Xiao Ming
AU - Li, Chun Shun
AU - Gao, Shu Shan
AU - Shang, Zhuo
AU - Wang, Bin Gui
PY - 2013/4
Y1 - 2013/4
N2 - Two new triazoles, chrysotriazoles A and B (1 and 2, resp.), along with two known quinazolinones, 3 and 4, two known 2-(4-hydroxyphenyl)acetamides, 5 and 6, and two known N-(4-hydroxystyryl)formamides, 7 and 8, were isolated and identified from the culture extract of Penicillium chrysogenum EN-118, an endophytic fungus obtained from the marine brown alga Sargassum pallidium. The structures of the isolated compounds were elucidated by NMR-spectroscopic analysis, and that of compound 1 was confirmed by X-ray crystallographic analysis of its p-bromobenzoate derivative. Compounds 4, 5, and 7 showed moderate cytotoxicities against Du145, A-549, and HeLa cell lines.
AB - Two new triazoles, chrysotriazoles A and B (1 and 2, resp.), along with two known quinazolinones, 3 and 4, two known 2-(4-hydroxyphenyl)acetamides, 5 and 6, and two known N-(4-hydroxystyryl)formamides, 7 and 8, were isolated and identified from the culture extract of Penicillium chrysogenum EN-118, an endophytic fungus obtained from the marine brown alga Sargassum pallidium. The structures of the isolated compounds were elucidated by NMR-spectroscopic analysis, and that of compound 1 was confirmed by X-ray crystallographic analysis of its p-bromobenzoate derivative. Compounds 4, 5, and 7 showed moderate cytotoxicities against Du145, A-549, and HeLa cell lines.
KW - Chrysotriazoles A and B
KW - Cytotoxic activity
KW - Penicillium chrysogenum
KW - Sargassum pallidium
UR - http://www.scopus.com/inward/record.url?scp=84876145329&partnerID=8YFLogxK
U2 - 10.1002/hlca.201200433
DO - 10.1002/hlca.201200433
M3 - Article
AN - SCOPUS:84876145329
SN - 0018-019X
VL - 96
SP - 682
EP - 687
JO - Helvetica Chimica Acta
JF - Helvetica Chimica Acta
IS - 4
ER -
