Trends in hepatocellular carcinoma due to non-alcoholic fatty liver disease

Research output: Contribution to journalReview article

Abstract

Introduction: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide and is associated with hepatocellular carcinoma (HCC), the most frequent malignant liver tumor. The increasing prevalence of obesity and diabetes is influencing the epidemiology of HCC with the most dramatic increases in NAFLD-related HCC seen in Western countries. Although cirrhosis is the major risk factor for HCC in NAFLD, there is increasing recognition that NAFLD-HCC occurs in the absence of cirrhosis. Areas covered: The epidemiology of NAFLD related HCC and its impact on changing the incidence of HCC globally. We overview risk factors for NAFLD-HCC in the presence and absence of cirrhosis and examine trends in liver transplantation (LT) related to NAFLD-HCC. Expert commentary: The incidence of NAFLD-related cirrhosis will continue to rise globally in parallel with risk factors of obesity and diabetes. Consequently, NAFLD-related HCC will become an increasingly important cause of liver-related morbidity and mortality and a common indication for LT worldwide. Further identification of risk factors for NAFLD-HCC and effective treatments for NAFLD are required to reduce this future burden of disease.

Original languageEnglish
Pages (from-to)179-187
Number of pages9
JournalExpert Review of Gastroenterology and Hepatology
Volume13
Issue number2
Early online date29 Dec 2018
DOIs
Publication statusPublished - 1 Feb 2019

Cite this

@article{77cc47f6f47b48349f5e21988a2f581b,
title = "Trends in hepatocellular carcinoma due to non-alcoholic fatty liver disease",
abstract = "Introduction: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide and is associated with hepatocellular carcinoma (HCC), the most frequent malignant liver tumor. The increasing prevalence of obesity and diabetes is influencing the epidemiology of HCC with the most dramatic increases in NAFLD-related HCC seen in Western countries. Although cirrhosis is the major risk factor for HCC in NAFLD, there is increasing recognition that NAFLD-HCC occurs in the absence of cirrhosis. Areas covered: The epidemiology of NAFLD related HCC and its impact on changing the incidence of HCC globally. We overview risk factors for NAFLD-HCC in the presence and absence of cirrhosis and examine trends in liver transplantation (LT) related to NAFLD-HCC. Expert commentary: The incidence of NAFLD-related cirrhosis will continue to rise globally in parallel with risk factors of obesity and diabetes. Consequently, NAFLD-related HCC will become an increasingly important cause of liver-related morbidity and mortality and a common indication for LT worldwide. Further identification of risk factors for NAFLD-HCC and effective treatments for NAFLD are required to reduce this future burden of disease.",
keywords = "Non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, hepatocellular carcinoma, liver cirrhosis, epidemiology, liver transplantation, RISK-FACTORS, DIABETES-MELLITUS, REDUCED RISK, ALCOHOLIC LIVER, HEPATITIS-B, JAPANESE PATIENTS, VIRAL-HEPATITIS, UNITED-STATES, FOLLOW-UP, STEATOHEPATITIS",
author = "Bertot, {Luis Calzadilla} and Adams, {Leon A.}",
year = "2019",
month = "2",
day = "1",
doi = "10.1080/17474124.2019.1549989",
language = "English",
volume = "13",
pages = "179--187",
journal = "Expert Review of Gastroenterology and Hepatology",
issn = "1747-4132",
publisher = "Taylor & Francis",
number = "2",

}

TY - JOUR

T1 - Trends in hepatocellular carcinoma due to non-alcoholic fatty liver disease

AU - Bertot, Luis Calzadilla

AU - Adams, Leon A.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Introduction: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide and is associated with hepatocellular carcinoma (HCC), the most frequent malignant liver tumor. The increasing prevalence of obesity and diabetes is influencing the epidemiology of HCC with the most dramatic increases in NAFLD-related HCC seen in Western countries. Although cirrhosis is the major risk factor for HCC in NAFLD, there is increasing recognition that NAFLD-HCC occurs in the absence of cirrhosis. Areas covered: The epidemiology of NAFLD related HCC and its impact on changing the incidence of HCC globally. We overview risk factors for NAFLD-HCC in the presence and absence of cirrhosis and examine trends in liver transplantation (LT) related to NAFLD-HCC. Expert commentary: The incidence of NAFLD-related cirrhosis will continue to rise globally in parallel with risk factors of obesity and diabetes. Consequently, NAFLD-related HCC will become an increasingly important cause of liver-related morbidity and mortality and a common indication for LT worldwide. Further identification of risk factors for NAFLD-HCC and effective treatments for NAFLD are required to reduce this future burden of disease.

AB - Introduction: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide and is associated with hepatocellular carcinoma (HCC), the most frequent malignant liver tumor. The increasing prevalence of obesity and diabetes is influencing the epidemiology of HCC with the most dramatic increases in NAFLD-related HCC seen in Western countries. Although cirrhosis is the major risk factor for HCC in NAFLD, there is increasing recognition that NAFLD-HCC occurs in the absence of cirrhosis. Areas covered: The epidemiology of NAFLD related HCC and its impact on changing the incidence of HCC globally. We overview risk factors for NAFLD-HCC in the presence and absence of cirrhosis and examine trends in liver transplantation (LT) related to NAFLD-HCC. Expert commentary: The incidence of NAFLD-related cirrhosis will continue to rise globally in parallel with risk factors of obesity and diabetes. Consequently, NAFLD-related HCC will become an increasingly important cause of liver-related morbidity and mortality and a common indication for LT worldwide. Further identification of risk factors for NAFLD-HCC and effective treatments for NAFLD are required to reduce this future burden of disease.

KW - Non-alcoholic fatty liver disease

KW - non-alcoholic steatohepatitis

KW - hepatocellular carcinoma

KW - liver cirrhosis

KW - epidemiology

KW - liver transplantation

KW - RISK-FACTORS

KW - DIABETES-MELLITUS

KW - REDUCED RISK

KW - ALCOHOLIC LIVER

KW - HEPATITIS-B

KW - JAPANESE PATIENTS

KW - VIRAL-HEPATITIS

KW - UNITED-STATES

KW - FOLLOW-UP

KW - STEATOHEPATITIS

U2 - 10.1080/17474124.2019.1549989

DO - 10.1080/17474124.2019.1549989

M3 - Review article

VL - 13

SP - 179

EP - 187

JO - Expert Review of Gastroenterology and Hepatology

JF - Expert Review of Gastroenterology and Hepatology

SN - 1747-4132

IS - 2

ER -