TY - JOUR
T1 - Treatment of macular telangiectasia type 2 with carotenoid supplements containing meso-zeaxanthin: A pilot study
AU - Tan, A.C.S.
AU - Balaratnasingam, Chandrakumar
AU - Yannuzzi, L.A.
PY - 2016/6
Y1 - 2016/6
N2 - © 2016, Slack Incorporated. All rights reserved.BACKGROUND AND OBJECTIVE: To assess the outcomes of patients with macular telangiectasia type 2 (MacTel 2) in response to lutein (L), meso-zeaxanthin (M), and zeaxanthin (Z) supplements (LMZ3). PATIENTS AND METHODS: Thirteen patients diagnosed with MacTel 2 were started on lutein 10 mg, meso-zeaxanthin 10 mg, and zeaxanthin 2 mg and were followed-up for a mean period of 15.7 months ± 4.85 months. RESULTS: Visual acuity improved in three patients (13%), and there was a reduction in the percentage of patients who had worsening vision (25% to 4%; P <.05). Optical coherence tomography changes showed a reduction in the number of cavitations and the largest diameter of the cavitation after the LMZ3 supplements were started. The largest diameter of photoreceptor disruption showed mild improvement in the first 6 months after LMZ3 supplements were started. CONCLUSION: LMZ3 supplements may stabilize vision and improve the cavitations in patients with MacTel 2. Larger randomized, controlled studies are required to verify these pilot results.
AB - © 2016, Slack Incorporated. All rights reserved.BACKGROUND AND OBJECTIVE: To assess the outcomes of patients with macular telangiectasia type 2 (MacTel 2) in response to lutein (L), meso-zeaxanthin (M), and zeaxanthin (Z) supplements (LMZ3). PATIENTS AND METHODS: Thirteen patients diagnosed with MacTel 2 were started on lutein 10 mg, meso-zeaxanthin 10 mg, and zeaxanthin 2 mg and were followed-up for a mean period of 15.7 months ± 4.85 months. RESULTS: Visual acuity improved in three patients (13%), and there was a reduction in the percentage of patients who had worsening vision (25% to 4%; P <.05). Optical coherence tomography changes showed a reduction in the number of cavitations and the largest diameter of the cavitation after the LMZ3 supplements were started. The largest diameter of photoreceptor disruption showed mild improvement in the first 6 months after LMZ3 supplements were started. CONCLUSION: LMZ3 supplements may stabilize vision and improve the cavitations in patients with MacTel 2. Larger randomized, controlled studies are required to verify these pilot results.
U2 - 10.3928/23258160-20160601-04
DO - 10.3928/23258160-20160601-04
M3 - Article
C2 - 27327282
SN - 2325-8160
VL - 47
SP - 528
EP - 535
JO - Ophthalmic Surgery Lasers and Imaging Retina
JF - Ophthalmic Surgery Lasers and Imaging Retina
IS - 6
ER -