Treatment of apathy in Parkinson’s disease

Sergio Starkstein, Simone Brockman

Research output: Chapter in Book/Conference paperChapter

Abstract

Apathy is defined as the loss of motivation expressed as diminished behaviours, intellectual activity, and emotional feelings and display. Apathy is present in approximately one third of cross-sectional samples of patients with Parkinson’s disease (PD) and is usually associated with depression and/or dementia. Apathy is more frequent in late stages of PD and has been reported as a side effect of deep brain stimulation. A recent trial demonstrated that the D2/D3 agonist piribedil may improve apathy in PD, but more controlled studies are needed.

Original languageEnglish
Title of host publicationTherapy of Movement Disorders
Subtitle of host publicationA Case-Based Approach
EditorsStephen G. Reich, Stewart A. Factor
Place of PublicationUSA
PublisherHumana Press
Pages117-119
Number of pages3
ISBN (Electronic)9783319978970
ISBN (Print)9783319978963
DOIs
Publication statusPublished - 1 Jan 2019

Publication series

NameCurrent Clinical Neurology
ISSN (Print)1559-0585
ISSN (Electronic)2524-4043

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  • Cite this

    Starkstein, S., & Brockman, S. (2019). Treatment of apathy in Parkinson’s disease. In S. G. Reich, & S. A. Factor (Eds.), Therapy of Movement Disorders: A Case-Based Approach (pp. 117-119). (Current Clinical Neurology). Humana Press. https://doi.org/10.1007/978-3-319-97897-0_28