Treatment of apathy in Parkinson’s disease

Sergio Starkstein, Simone Brockman

Research output: Chapter in Book/Conference paperChapterpeer-review


Apathy is defined as the loss of motivation expressed as diminished behaviours, intellectual activity, and emotional feelings and display. Apathy is present in approximately one third of cross-sectional samples of patients with Parkinson’s disease (PD) and is usually associated with depression and/or dementia. Apathy is more frequent in late stages of PD and has been reported as a side effect of deep brain stimulation. A recent trial demonstrated that the D2/D3 agonist piribedil may improve apathy in PD, but more controlled studies are needed.

Original languageEnglish
Title of host publicationTherapy of Movement Disorders
Subtitle of host publicationA Case-Based Approach
EditorsStephen G. Reich, Stewart A. Factor
Place of PublicationUSA
PublisherHumana Press Inc.
Number of pages3
ISBN (Electronic)9783319978970
ISBN (Print)9783319978963
Publication statusPublished - 1 Jan 2019

Publication series

NameCurrent Clinical Neurology
ISSN (Print)1559-0585
ISSN (Electronic)2524-4043


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