Treadmill running exercise prevents senile osteoporosis and upregulates the Wnt signaling pathway in SAMP6 mice

X. Chen, L. Li, J. Guo, L. Zhang, Y. Yuan, B. Chen, Z. Sun, Jiake Xu, J. Zou

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    This study examined the effects of different exercise intensities and durations on bone mineral density (BMD) and bone strength in senescence-accelerated mouse prone 6 (SAMP6) and determined the involvement of the Wnt signaling pathway in exercise-induced osteogenesis. Three-month-old male SAMP6 mice were randomly assigned to different speeds of treadmill running exercise representing low, medium and high intensity, with the duration of five and nine weeks, respectively. We showed that medium-intensity exercise had positive effects on skeletal health, including BMD and bone strength, and the efficacy was higher than that of low-intensity exercise. Interestingly, high-intensity exercise can maintain or even increase bone strength, despite its negative effects on bone mass. Nine weeks of exercise was superior to 5 weeks of exercise, particularly for low-intensity exercise. Furthermore, these effects of exercise-induced osteogenesis are accompanied by activation of the Wnt signaling pathway. Taken together, these results suggest that the positive effects of exercise on osteoporosis prevention are intensity and duration-dependent, and may involve the regulation of Wnt signaling pathways.
    Original languageEnglish
    Pages (from-to)71072-71086
    Number of pages15
    JournalOncotarget
    Volume7
    Issue number44
    DOIs
    Publication statusPublished - 2016

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    Wnt Signaling Pathway
    Running
    Osteoporosis
    Up-Regulation
    Bone and Bones
    Osteogenesis
    Bone Density
    Health

    Cite this

    Chen, X. ; Li, L. ; Guo, J. ; Zhang, L. ; Yuan, Y. ; Chen, B. ; Sun, Z. ; Xu, Jiake ; Zou, J. / Treadmill running exercise prevents senile osteoporosis and upregulates the Wnt signaling pathway in SAMP6 mice. In: Oncotarget. 2016 ; Vol. 7, No. 44. pp. 71072-71086.
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    abstract = "This study examined the effects of different exercise intensities and durations on bone mineral density (BMD) and bone strength in senescence-accelerated mouse prone 6 (SAMP6) and determined the involvement of the Wnt signaling pathway in exercise-induced osteogenesis. Three-month-old male SAMP6 mice were randomly assigned to different speeds of treadmill running exercise representing low, medium and high intensity, with the duration of five and nine weeks, respectively. We showed that medium-intensity exercise had positive effects on skeletal health, including BMD and bone strength, and the efficacy was higher than that of low-intensity exercise. Interestingly, high-intensity exercise can maintain or even increase bone strength, despite its negative effects on bone mass. Nine weeks of exercise was superior to 5 weeks of exercise, particularly for low-intensity exercise. Furthermore, these effects of exercise-induced osteogenesis are accompanied by activation of the Wnt signaling pathway. Taken together, these results suggest that the positive effects of exercise on osteoporosis prevention are intensity and duration-dependent, and may involve the regulation of Wnt signaling pathways.",
    author = "X. Chen and L. Li and J. Guo and L. Zhang and Y. Yuan and B. Chen and Z. Sun and Jiake Xu and J. Zou",
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    Treadmill running exercise prevents senile osteoporosis and upregulates the Wnt signaling pathway in SAMP6 mice. / Chen, X.; Li, L.; Guo, J.; Zhang, L.; Yuan, Y.; Chen, B.; Sun, Z.; Xu, Jiake; Zou, J.

    In: Oncotarget, Vol. 7, No. 44, 2016, p. 71072-71086.

    Research output: Contribution to journalArticle

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    AU - Chen, B.

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    AB - This study examined the effects of different exercise intensities and durations on bone mineral density (BMD) and bone strength in senescence-accelerated mouse prone 6 (SAMP6) and determined the involvement of the Wnt signaling pathway in exercise-induced osteogenesis. Three-month-old male SAMP6 mice were randomly assigned to different speeds of treadmill running exercise representing low, medium and high intensity, with the duration of five and nine weeks, respectively. We showed that medium-intensity exercise had positive effects on skeletal health, including BMD and bone strength, and the efficacy was higher than that of low-intensity exercise. Interestingly, high-intensity exercise can maintain or even increase bone strength, despite its negative effects on bone mass. Nine weeks of exercise was superior to 5 weeks of exercise, particularly for low-intensity exercise. Furthermore, these effects of exercise-induced osteogenesis are accompanied by activation of the Wnt signaling pathway. Taken together, these results suggest that the positive effects of exercise on osteoporosis prevention are intensity and duration-dependent, and may involve the regulation of Wnt signaling pathways.

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