Transmission Electron Microscopy Data on drusen-like deposits in the retinal degeneration sTg-IRBP: HEL mouse model

Yi-Hsia Liu, Christine Molzer, Gillian C. Milne, Lucia Kuffova, John V. Forrester

Research output: Contribution to journalArticle

Abstract

Histology (H&E) and transmission electron microscopy (TEM) data are provided showing age-related changes in the retinal structure of sTg-IRBP:HEL mice. These include substantial photoreceptor loss, atrophy of the retinal pigment epithelium, Bruch's membrane disruption and thickening, along with the presence of drusenoid deposits and changes in basal laminar infoldings. These features resemble some of those key characteristics found in the course of human dry (atrophic) age-related macular degeneration (AMD), particularly with regard to drusen. Hence, we believe the sTg-IRBP: HEL mouse model represents a useful and promising archetype for future study of the mechanism of drusen formation in AMD. (C) 2018 The Authors. Published by Elsevier Inc.

Original languageEnglish
Pages (from-to)140-144
Number of pages5
JournalData in Brief
Volume22
DOIs
Publication statusPublished - Feb 2019

Cite this

Liu, Yi-Hsia ; Molzer, Christine ; Milne, Gillian C. ; Kuffova, Lucia ; Forrester, John V. / Transmission Electron Microscopy Data on drusen-like deposits in the retinal degeneration sTg-IRBP : HEL mouse model. In: Data in Brief. 2019 ; Vol. 22. pp. 140-144.
@article{33a30b19e6c2415ea88f0ea1d9fbbaa4,
title = "Transmission Electron Microscopy Data on drusen-like deposits in the retinal degeneration sTg-IRBP: HEL mouse model",
abstract = "Histology (H&E) and transmission electron microscopy (TEM) data are provided showing age-related changes in the retinal structure of sTg-IRBP:HEL mice. These include substantial photoreceptor loss, atrophy of the retinal pigment epithelium, Bruch's membrane disruption and thickening, along with the presence of drusenoid deposits and changes in basal laminar infoldings. These features resemble some of those key characteristics found in the course of human dry (atrophic) age-related macular degeneration (AMD), particularly with regard to drusen. Hence, we believe the sTg-IRBP: HEL mouse model represents a useful and promising archetype for future study of the mechanism of drusen formation in AMD. (C) 2018 The Authors. Published by Elsevier Inc.",
author = "Yi-Hsia Liu and Christine Molzer and Milne, {Gillian C.} and Lucia Kuffova and Forrester, {John V.}",
year = "2019",
month = "2",
doi = "10.1016/j.dib.2018.12.007",
language = "English",
volume = "22",
pages = "140--144",
journal = "Data in Brief",
issn = "2352-3409",
publisher = "Pergamon",

}

Transmission Electron Microscopy Data on drusen-like deposits in the retinal degeneration sTg-IRBP : HEL mouse model. / Liu, Yi-Hsia; Molzer, Christine; Milne, Gillian C.; Kuffova, Lucia; Forrester, John V.

In: Data in Brief, Vol. 22, 02.2019, p. 140-144.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Transmission Electron Microscopy Data on drusen-like deposits in the retinal degeneration sTg-IRBP

T2 - HEL mouse model

AU - Liu, Yi-Hsia

AU - Molzer, Christine

AU - Milne, Gillian C.

AU - Kuffova, Lucia

AU - Forrester, John V.

PY - 2019/2

Y1 - 2019/2

N2 - Histology (H&E) and transmission electron microscopy (TEM) data are provided showing age-related changes in the retinal structure of sTg-IRBP:HEL mice. These include substantial photoreceptor loss, atrophy of the retinal pigment epithelium, Bruch's membrane disruption and thickening, along with the presence of drusenoid deposits and changes in basal laminar infoldings. These features resemble some of those key characteristics found in the course of human dry (atrophic) age-related macular degeneration (AMD), particularly with regard to drusen. Hence, we believe the sTg-IRBP: HEL mouse model represents a useful and promising archetype for future study of the mechanism of drusen formation in AMD. (C) 2018 The Authors. Published by Elsevier Inc.

AB - Histology (H&E) and transmission electron microscopy (TEM) data are provided showing age-related changes in the retinal structure of sTg-IRBP:HEL mice. These include substantial photoreceptor loss, atrophy of the retinal pigment epithelium, Bruch's membrane disruption and thickening, along with the presence of drusenoid deposits and changes in basal laminar infoldings. These features resemble some of those key characteristics found in the course of human dry (atrophic) age-related macular degeneration (AMD), particularly with regard to drusen. Hence, we believe the sTg-IRBP: HEL mouse model represents a useful and promising archetype for future study of the mechanism of drusen formation in AMD. (C) 2018 The Authors. Published by Elsevier Inc.

U2 - 10.1016/j.dib.2018.12.007

DO - 10.1016/j.dib.2018.12.007

M3 - Article

VL - 22

SP - 140

EP - 144

JO - Data in Brief

JF - Data in Brief

SN - 2352-3409

ER -