Translating animal model research: Does it matter that our rodents are cold?

Shane Maloney, A. Fuller, Duncan Mitchell, C.J. Gordon, J. Michael Overton

    Research output: Contribution to journalArticle

    76 Citations (Scopus)

    Abstract

    © 2014 Int. Union Physiol. Sci./Am. Physiol. Soc. Does it matter that rodents used as preclinical models of human biology are routinely housed below their thermoneutral zone? We compile evidence showing that such rodents are cold-stressed, hypermetabolic, hypertensive, sleep-deprived, obesity-resistant, fever-resistant, aging-resistant, and tumorprone compared with mice housed at thermoneutrality. The same genotype of mouse has a very different phenotype and response to physiological or pharmacological intervention when raised below or at thermoneutrality.
    Original languageEnglish
    Pages (from-to)413-420
    JournalPhysiology
    Volume29
    Issue number6
    DOIs
    Publication statusPublished - 2014

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