Transition metal-free methylation of amines with formaldehyde as the reductant and methyl source

Nikki Man, W. Li, Scott Stewart, X.F. Wu

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

© Schweizerische Chemische Gesellschaft. A simple transition metal-free procedure using formaldehyde for the N,N-dimethylation and N-methylation of primary and secondary anilines is reported. The reaction showed limitations on sterically hindered and electron-withdrawing anilines, but is successful on amines with electron-donating substituents. Formaldehyde acts as both the reducing agent and the carbon source in the reaction.
Original languageEnglish
Pages (from-to)345-347
JournalChimia
Volume69
Issue number6
DOIs
Publication statusPublished - 2015

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