Transition-Metal-Free Cross-Coupling Reactions in Dynamic Thin Films To Access Pyrimidine and Quinoxaline Analogues

Louisa A. Ho, C.L. Raston, Keith A. Stubbs

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

The vortex fluidic device (VFD) is effective in modulating the synthesis of pyrimidine and quinoxaline-based compounds at room temperature and in high yield. The formation of the C–N bond occurs in the absence of a transition-metal catalyst, which avoids the contamination of the products with trace amounts of a transition metal. The systematic investigation of the operating parameters for the microfluidic platform in the confined operation mode established an optimum tilt angle of 45° for a 10 mm diameter borosilicate glass tube rotating at 5000 rpm.

Original languageEnglish
Pages (from-to)5957-5963
JournalEuropean Journal of Organic Chemistry
Volume2016
Issue number36
Early online date28 Nov 2016
DOIs
Publication statusPublished - Dec 2016

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