Abstract
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
The vortex fluidic device (VFD) is effective in modulating the synthesis of pyrimidine and quinoxaline-based compounds at room temperature and in high yield. The formation of the C–N bond occurs in the absence of a transition-metal catalyst, which avoids the contamination of the products with trace amounts of a transition metal. The systematic investigation of the operating parameters for the microfluidic platform in the confined operation mode established an optimum tilt angle of 45° for a 10 mm diameter borosilicate glass tube rotating at 5000 rpm.
| Original language | English |
|---|---|
| Pages (from-to) | 5957-5963 |
| Journal | European Journal of Organic Chemistry |
| Volume | 2016 |
| Issue number | 36 |
| Early online date | 28 Nov 2016 |
| DOIs | |
| Publication status | Published - Dec 2016 |
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Cite this
Ho, L. A., Raston, C. L., & Stubbs, K. A. (2016). Transition-Metal-Free Cross-Coupling Reactions in Dynamic Thin Films To Access Pyrimidine and Quinoxaline Analogues. European Journal of Organic Chemistry, 2016(36), 5957-5963. https://doi.org/10.1002/ejoc.201600830