Abstract
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
The vortex fluidic device (VFD) is effective in modulating the synthesis of pyrimidine and quinoxaline-based compounds at room temperature and in high yield. The formation of the C–N bond occurs in the absence of a transition-metal catalyst, which avoids the contamination of the products with trace amounts of a transition metal. The systematic investigation of the operating parameters for the microfluidic platform in the confined operation mode established an optimum tilt angle of 45° for a 10 mm diameter borosilicate glass tube rotating at 5000 rpm.
Original language | English |
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Pages (from-to) | 5957-5963 |
Journal | European Journal of Organic Chemistry |
Volume | 2016 |
Issue number | 36 |
Early online date | 28 Nov 2016 |
DOIs | |
Publication status | Published - Dec 2016 |