TY - JOUR
T1 - Transient up-regulation of retinal EphA3 and EphA5, but not eprhin-A2, coincides with re-establishment of a topographic map during optic nerve regeneration in goldfish
AU - King, C.E.
AU - Wallace, A.
AU - Rodger, Jennifer
AU - Bartlett, Carole
AU - Beazley, Lyn
AU - Dunlop, Sarah
PY - 2003
Y1 - 2003
N2 - Eph tyrosine kinase receptors and their ligands, the ephrins, play a key role in the establishment of retinotectal topography during development. Tectal up-regulation of ephrin-A2 in goldfish, coincident with the reestablishment of a retinotectal map, suggests a similar role during optic nerve regeneration [Rodger et al 2000]. Here we report a complementary study of EphA3, EphA5 and ephrin-A2 expression in the retina. EphA3 and EphA5 are transiently up-regulated as ascending naso-temporal gradients, whereas ephrin-A2 remains uniform. The expression profiles differ from those in developing chick and mouse, suggesting that different combinations of retinal Eph receptors and ligands can generate topographic guidance information.
AB - Eph tyrosine kinase receptors and their ligands, the ephrins, play a key role in the establishment of retinotectal topography during development. Tectal up-regulation of ephrin-A2 in goldfish, coincident with the reestablishment of a retinotectal map, suggests a similar role during optic nerve regeneration [Rodger et al 2000]. Here we report a complementary study of EphA3, EphA5 and ephrin-A2 expression in the retina. EphA3 and EphA5 are transiently up-regulated as ascending naso-temporal gradients, whereas ephrin-A2 remains uniform. The expression profiles differ from those in developing chick and mouse, suggesting that different combinations of retinal Eph receptors and ligands can generate topographic guidance information.
U2 - 10.1016/S0014-4886(03)00211-5
DO - 10.1016/S0014-4886(03)00211-5
M3 - Article
SN - 0014-4886
VL - 183
SP - 593
EP - 599
JO - Experimental Neurology
JF - Experimental Neurology
IS - 2
ER -